Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C11H17NO.ClH |
Molecular Weight | 215.72 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C[C@H]([C@@H](O)C1=CC=CC=C1)N(C)C
InChI
InChIKey=NTCYWJCEOILKNG-FOKYBFFNSA-N
InChI=1S/C11H17NO.ClH/c1-9(12(2)3)11(13)10-7-5-4-6-8-10;/h4-9,11,13H,1-3H3;1H/t9-,11-;/m1./s1
Molecular Formula | C11H17NO |
Molecular Weight | 179.2588 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/2327112Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/9681334
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=1310.12
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2327112
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/9681334
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=1310.12
Methylephedrine is one of the ephedra alkaloids that is found in varying amounts in different species of the plant genus Ephedra. Methylephedrine is a popular antitussive, bronchodilator, analgesic, antipyretic, and widely used mixed with other drugs in preparations for treatment of the common cold. N-Methylephedrine, its salts, optical isomers, and salts of optical isomers are in FDA list of Exempt chemical mixtures.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Histamine receptors Sources: https://www.ncbi.nlm.nih.gov/pubmed/8990487 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Palliative | Sanwa Approved UseIt is usually used in the treatment of cough associated with diseases such as bronchial asthma, cold, acute or chronic bronchitis, pulmonary tuberculosis, and upper airway inflammation. |
PubMed
Title | Date | PubMed |
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[Comparative studies on a broncholytic and circulatory effect of methylephedrine and ephedrine]. | 1970 Feb 15 |
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[Broncholytic effect of methylephedrine in acute study]. | 1974 Sep |
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[Caffeine-11C, ephedrine-11C and methylephedrine-11C: Synthesis and distribution in mice (author's transl)]. | 1978 Aug |
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Methylephedrine concentrations in blood and urine specimens. | 1998 Jul-Aug |
Patents
Sample Use Guides
Take 0.25-0.5 g (25-50 mg of the active ingredient) at a time, 3 times daily
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8910253
l-MEP inhibited the twitch response at high concentrations (3 x 10(-5)-10(-3) M). On the other hand, d-MEP showed the potentiation of twitch response, and competitively antagonized the twitch-inhibitory effect of clonidine (10(-9)-10(-6) M) with the pA2 value of 4.3 in the presence of prazosin.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 04:36:33 GMT 2023
by
admin
on
Sat Dec 16 04:36:33 GMT 2023
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Record UNII |
P982XVV768
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Record Status |
Validated (UNII)
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Record Version |
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m7410
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PRIMARY | Merck Index |