Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C3H4N2.BrH |
| Molecular Weight | 148.989 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Br.N1C=CN=C1
InChI
InChIKey=VWUCIBOKNZGWLX-UHFFFAOYSA-N
InChI=1S/C3H4N2.BrH/c1-2-5-3-4-1;/h1-3H,(H,4,5);1H
| Molecular Formula | BrH |
| Molecular Weight | 80.912 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C3H4N2 |
| Molecular Weight | 68.0773 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Imidazole salicylate (also known as ITF-182), a nonsteroidal anti-inflammatory drug (NSAID) that inhibits Tromboxane A2 synthesis, without interfering with cyclo-oxygenase pathway and possesses the limited inhibitory effects on prostaglandin synthesis. Imidazole salicylate can be used for the treatment of osteoarthrosis and musculoskeletal trauma. In addition, it can be given to patients with decompensated cirrhosis without risk of inhibiting kidney prostaglandin synthesis. Imidazole salicylate was characterized by good gastric tolerability and could be assigned for treatment of rheumatic diseases in the elderly. The drug also can be safely used in aspirin-sensitive patients.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Imidazole salicylate in the treatment of osteoarthrosis and musculoskeletal trauma: a postmarketing survey. | 1988 |
|
| Imidazole salicylate versus piroxicam in the treatment of arthrosis in elderly patients. A double-blind clinical and endoscopic trial. | 1990 Sep |
|
| Blood binding of selezen (imidazole salicylate) in man. | 1991 Jun |
|
| Double-blind randomized clinical trial on imidazole salicylate vs ibuprofen in osteoarthritis. | 1991 May |
|
| Effects of imidazole-salicylate on renal function and the diuretic action of furosemide in cirrhotic patients with ascites. | 1993 Sep |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:53:41 GMT 2023
by
admin
on
Sat Dec 16 10:53:41 GMT 2023
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| Record UNII |
P8OZC543Y6
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID901335873
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12203052
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101023-55-6
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P8OZC543Y6
Created by
admin on Sat Dec 16 10:53:41 GMT 2023 , Edited by admin on Sat Dec 16 10:53:41 GMT 2023
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