N-ETHYL-N-NITROSOUREA

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H7N3O2
Molecular Weight	117.1066
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(N=O)C(N)=O

InChI

InChIKey=FUSGACRLAFQQRL-UHFFFAOYSA-N

InChI=1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)

HIDE SMILES / InChI

Molecular Formula	C3H7N3O2
Molecular Weight	117.1066
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
The antimalarials quinacrine and chloroquine potentiate the transplacental carcinogenic effect of ethylnitrosourea on ependymal cells.	2001	11908878
ENU mutagenesis: analyzing gene function in mice.	2001	11701658
Possible role of K-ras oncogene in mutagenic activity of ethylnitrosourea on lymphocyte hyperproliferation in rat colon.	2001 Aug	11732210
Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract.	2001 Dec	11846517
[A large-scale mouse mutagenesis with a chemical mutagen ENU].	2001 Dec	11802439
Chemoprevention of mammary, cervix and nervous system carcinogenesis in animals using cultured Panax ginseng drugs and preliminary clinical trials in patients with precancerous lesions of the esophagus and endometrium.	2001 Dec	11748376
Different mutation status of the beta-catenin gene in carcinogen-induced colon, brain, and oral tumors in rats.	2001 Dec	11746832
Establishing an ENU mutagenesis screen for the piebald region of mouse Chromosome 14.	2001 Dec	11707782
Induction of lacI mutations in Big Blue Rat-2 cells treated with 1-(2-hydroxyethyl)-1-nitrosourea: a model system for the analysis of mutagenic potential of the hydroxyethyl adducts produced by 1,3-bis (2-chloroethyl)-1-nitrosourea.	2001 Dec 12	11733074
Detection of DNA adducts using a quantitative long PCR technique and the fluorogenic 5' nuclease assay (TaqMan).	2001 Dec 12	11733068
Neural precursor cell apoptosis and glial tumorigenesis following transplacental ethyl-nitrosourea exposure.	2001 Dec 13	11781843
Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas.	2001 Jul	11718257
[ENU induced mutagenesis-large-scale study of gene mutagenesis and function].	2001 Jul	11702688
Paradoxical effect of aspirin on the growth of C6 rat glioma and on time of development of ENU-induced tumors of the nervous system.	2001 Nov	11710598
Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene.	2001 Nov	11687536
The importance of distinct metabolites of N-nitrosodiethylamine for its in vivo mutagenic specificity.	2001 Nov 1	11600138
Overexpression of Ogt reduces MNU and ENU induced transition, but not transversion, mutations in E. coli.	2001 Nov 1	11595408
Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic.	2001 Oct	11817103
The selenocysteine incorporation machinery: interactions between the SECIS RNA and the SECIS-binding protein SBP2.	2001 Oct	11680849
Cell type-specific induction of O6-alkylguanine-DNA alkyltransferase mRNA expression in rat liver during regeneration, inflammation and preneoplasia.	2001 Oct	11599795
[Induction of tumors of the sympathetic nervous system in rats].	2002	12101567
Focusing on the genetics of hearing: you ain't heard nothin' yet.	2002	12093367
A comparative study of cytotoxic effects of N-ethyl-N-nitrosourea, adriamycin, and mono-(2-ethylhexyl)phthalate on mouse primordial germ cells.	2002	12046691
ENU-induced ovarian cancer.	2002	11987552
ENU mutagenesis of rat mammary epithelial cells.	2002	11987551
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutagenesis in cultured Big Blue rat mammary epithelial and fibroblast cells.	2002	11921195
2001: a mouse genome odyssey.	2002	11864368
In search of new disease models in the mouse using ENU mutagenesis.	2002	11859561
Characterization of mutant spectra generated by a forward mutational assay for gene A of Phi X174 from ENU-treated transgenic mouse embryonic cell line PX-2.	2002	11813297
Identifying tumor vascular permeability heterogeneity with magnetic resonance imaging contrast agents.	2002 Apr	11923640
Novel approaches for identifying genes regulating lymphocyte development and function.	2002 Apr	11869902
Novel ENU-induced eye mutations in the mouse: models for human eye disease.	2002 Apr 1	11929848
Acceleration of G(1) cooperates with core binding factor beta-smooth muscle myosin heavy chain to induce acute leukemia in mice.	2002 Apr 15	11956074
Zebrafish mutagenesis yields eye morphological mutants with retinal and lens defects.	2002 Feb	11853770
Generating mouse models of retinal disease using ENU mutagenesis.	2002 Feb	11853764
Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.	2002 Feb	11818962
Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice.	2002 Feb 15	11815254
Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats.	2002 Jan	11773517
Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats.	2002 Jan	11773516
Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard.	2002 Jan 7	11857024
Evidence for translational regulation of the imprinted Snurf-Snrpn locus in mice.	2002 Jul 1	12075010
Target-selected inactivation of the zebrafish rag1 gene.	2002 Jul 5	12098699
Loss of heterozygosity in malignant rat schwannomas chemically induced in hybrids of inbred rat strains with differential tumor susceptibility.	2002 Jun	12082026
Influence of mus201 and mus308 mutations of Drosophila melanogaster on the genotoxicity of model chemicals in somatic cells in vivo measured with the comet assay.	2002 Jun 19	12052499
ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis.	2002 Mar	11919684
Modified immunoenriched (32)P-HPLC assay for the detection of O(4)-ethylthymidine in human biomonitoring studies.	2002 Mar	11896692
Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the thymidine kinase gene of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells.	2002 Mar	11880538
A gene-driven approach to the identification of ENU mutants in the mouse.	2002 Mar	11850622
Dynamic MRI enhanced with albumin-(Gd-DTPA)30 or ultrasmall superparamagnetic iron oxide particles (NC100150 injection) for the measurement of microvessel permeability in experimental breast tumors.	2002 May	12019843
Down-regulation of von Hippel-Lindau protein in N-nitroso compound-induced rat non-clear cell renal tumors.	2002 May 8	11880179

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:41:31 GMT 2023` Edited by `admin` on `Fri Dec 15 16:41:31 GMT 2023`
Record UNII	P8M1T4190R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-ETHYL-N-NITROSOUREA

Systematic Name

English

ENU

Common Name

English

N-NITROSO-N-ETHYLUREA [HSDB]

Common Name

English

N-ETHYL-N-NITROSOUREA [MI]

Common Name

English

N-NITROSO-N-ETHYLUREA

Systematic Name

English

ETHYL-1-NITROSOUREA, 1-

Systematic Name

English

1-ETHYL-1-NITROSOUREA

Systematic Name

English

NSC-45403

Code

English

N-ETHYL-N-NITROSOUREA [IARC]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C26563