Efmedaglutide Alfa

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 20:44:58 GMT 2025` Edited by `admin` on `Wed Apr 02 20:44:58 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	P7M6NNA87N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

7-37-Glucagon-like peptide 1 [8-glycine] (human) fusion protein with immunoglobulin (human hybrid ?-chain hinge-CH2 fragment/?4-chain CH2-CH3 fragment), dimer

Preferred Name

English

Efmedaglutide Alfa

Official Name

English

human glucagon-like peptide-1 (GLP-1) (7-37, 1-31 in the current sequence), variant (A<sup>8</sup>>G<sup>2</sup>), fused to a hybrid Fc fragment of human immunoglobulin delta/gamma 4 (32-286) [Homo sapiens IGHD*01 (hinge (32-68), CH2 (69-78)), Homo sapie

Common Name

English

efmedaglutide alfa [INN]

Common Name

English

Code System Code Type Description

INN

13131

Created by admin on Wed Apr 02 20:44:58 GMT 2025 , Edited by admin on Wed Apr 02 20:44:58 GMT 2025

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NCI_THESAURUS

C211793

Created by admin on Wed Apr 02 20:44:58 GMT 2025 , Edited by admin on Wed Apr 02 20:44:58 GMT 2025

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FDA UNII

P7M6NNA87N

Created by admin on Wed Apr 02 20:44:58 GMT 2025 , Edited by admin on Wed Apr 02 20:44:58 GMT 2025

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CAS

2919801-97-9

Created by admin on Wed Apr 02 20:44:58 GMT 2025 , Edited by admin on Wed Apr 02 20:44:58 GMT 2025

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From	To
1_70	2_70
2_206	2_264
2_100	2_160
1_206	1_264
1_100	1_160

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_136
N	2_136
O	1_5
O	1_35
O	1_36
O	1_40
O	1_41
O	2_5
O	2_35
O	2_36
O	2_40
O	2_41

Related Record Type Details


					EF38T7N5MI

GLUCAGON-LIKE PEPTIDE 1 RECEPTOR

TARGET -> AGONIST

Amount:

Related Record Type Details


					P7M6NNA87N

Efmedaglutide Alfa

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_286] [2_286]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL