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Details

Stereochemistry UNKNOWN
Molecular Formula C13H16N2
Molecular Weight 200.2795
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TETRAHYDROZOLINE, (-)-

SMILES

C1CN=C(N1)C2CCCC3=C2C=CC=C3

InChI

InChIKey=BYJAVTDNIXVSPW-UHFFFAOYSA-N
InChI=1S/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15)

HIDE SMILES / InChI

Molecular Formula C13H16N2
Molecular Weight 200.2795
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Tetrahydrozoline is an alpha adrenergic receptor agonist, which is used in form of nasal solution or spray (Tyzin) for decongestion of nasal and nasopharyngeal mucosa.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
TYZINE

Cmax

ValueDoseCo-administeredAnalytePopulation
0.218 ng/mL
2 drop 4 times / day multiple, ocular
TETRAHYDROZOLINE serum
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
3.46 ng × h/mL
2 drop 4 times / day multiple, ocular
TETRAHYDROZOLINE serum
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
6 h
2 drop 4 times / day multiple, ocular
TETRAHYDROZOLINE serum
Homo sapiens

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
Adults and Children 6 Years and Over, Tyzine 0.1% Nasal Solution: It is recommended that 2 to 4 drops be instilled in each nostril as needed, never more often than every three hours. Adults and Children 6 Years and Over, Tyzine 0.1% Nasal Spray: It is recommended to squeeze quickly and firmly three or four times the spray in each nostril as needed, never more often than every three hours. Children 2 to 6 Years of Age, Tyzine 0.05 % Pediatric Nasal Drops: It is recommended that 2 to 3 drops be instilled in each nostril as needed, and never more often than every three hours.
Route of Administration: Nasal
In Vitro Use Guide
Rat and rabbit aortae were treated with tetrahydrozoline at concentrations from 10(-7) to 10(-5) M to determine the drug relative efficacy. Emax value was 0.51 for the rabbit aortae and 0 for the rat aortae.
Substance Class Chemical
Record UNII
P7M4KML3S8
Record Status Validated (UNII)
Record Version