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Details

Stereochemistry ACHIRAL
Molecular Formula C12H18N4O4PS.Cl
Molecular Weight 380.787
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MONOPHOSPHOTHIAMINE

SMILES

[Cl-].CC1=C(CCOP(O)(O)=O)SC=[N+]1CC2=CN=C(C)N=C2N

InChI

InChIKey=GUGWNSHJDUEHNJ-UHFFFAOYSA-N
InChI=1S/C12H17N4O4PS.ClH/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19);1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C12H17N4O4PS
Molecular Weight 344.327
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Monophosphothiamine is thiamine derivative used for the treatment of neuritis, polyneuritis, asthenic conditions (weakness), as an additional remedy for chronic blood circulation insufficiency, chronic gastritis accompanied by motor and secretory disorders functions of the stomach. Monophosphothiamine underwent metabolic phosphorylation to active metabolite thiamine pyrophosphate, that acts as a coenzyme in the different metabolic process.

Originator

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
[Separation by ion exchange chromatography and spectrophotometric determination of cocarboxylase, monophosphothiamine and thiamine].
1971
Patents

Patents

SU137920
4

Sample Use Guides

In Vivo Use Guide
0,01 - 0.03 g 3-4 times a day (after food) for 3-4 weeks.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Wed Apr 02 09:53:17 GMT 2025
Edited
by admin
on Wed Apr 02 09:53:17 GMT 2025
Record UNII
P712T71Q3T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MONOPHOSPHOTHIAMINE
INN   WHO-DD  
INN  
Official Name English
THIAMINE MONOPHOSPHATE
MI  
Preferred Name English
THIAMINE PHOSPHORIC ACID ESTER CHLORIDE
Common Name English
NOVOBETA
Brand Name English
THIAMINE MONOPHOSPHATE [MI]
Common Name English
SUPERNEURINA
Brand Name English
THIAMINE MONOPHOSPHATE CHLORIDE
Common Name English
Monophosphothiamine [WHO-DD]
Common Name English
NOVANEURINA
Brand Name English
FOSBIONE
Brand Name English
THIAZOLIUM, 3-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)-4-METHYL-5-(2-(PHOSPHONOOXY)ETHYL)-, CHLORIDE (1:1)
Systematic Name English
SINEURINA
Brand Name English
monophosphothiamine [INN]
Common Name English
PHOSPHOTHIAMINE
Common Name English
TMP (THIAMINE ESTER)
Common Name English
PHOSBITAMIN
Brand Name English
PHOSPHOTHIAMIN
Common Name English
VITAMIN B1 MONOPHOSPHATE CHLORIDE
Common Name English
NEURIFOSFORIL
Brand Name English
EXTRANEURINA
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C26017
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
Code System Code Type Description
EPA CompTox
DTXSID6046397
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
SMS_ID
100000080381
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
EVMPD
SUB09052MIG
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
PUBCHEM
10761
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
NCI_THESAURUS
C66188
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
ChEMBL
CHEMBL1236378
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
ECHA (EC/EINECS)
208-536-9
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
CHEBI
18338
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
MERCK INDEX
m10718
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY Merck Index
CHEBI
9533
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
FDA UNII
P712T71Q3T
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
CAS
532-40-1
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
INN
702
Created by admin on Wed Apr 02 09:53:17 GMT 2025 , Edited by admin on Wed Apr 02 09:53:17 GMT 2025
PRIMARY
Related Record Type Details
Structure of MONOPHOSPHOTHIAMINE DIHYDRATE
SOLVATE->ANHYDROUS
Structure of MONOPHOSPHOTHIAMINE DIHYDRATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of MONOPHOSPHOTHIAMINE INNER SALT
ACTIVE MOIETY
NIH
NCATS
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