MONOPHOSPHOTHIAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H18N4O4PS.Cl
Molecular Weight	380.787
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].CC1=C(CCOP(O)(O)=O)SC=[N+]1CC2=CN=C(C)N=C2N

InChI

InChIKey=GUGWNSHJDUEHNJ-UHFFFAOYSA-N

InChI=1S/C12H17N4O4PS.ClH/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C12H17N4O4PS
Molecular Weight	344.327
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5151224 | https://www.ncbi.nlm.nih.gov/pubmed/5734623 | https://www.ncbi.nlm.nih.gov/pubmed/676062 | https://www.rlsnet.ru/tn_index_id_5374.htm

Monophosphothiamine is thiamine derivative used for the treatment of neuritis, polyneuritis, asthenic conditions (weakness), as an additional remedy for chronic blood circulation insufficiency, chronic gastritis accompanied by motor and secretory disorders functions of the stomach. Monophosphothiamine underwent metabolic phosphorylation to active metabolite thiamine pyrophosphate, that acts as a coenzyme in the different metabolic process.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Separation by ion exchange chromatography and spectrophotometric determination of cocarboxylase, monophosphothiamine and thiamine].	1971	5151224

Patents

Sample Use Guides

In Vivo Use Guide

0,01 - 0.03 g 3-4 times a day (after food) for 3-4 weeks.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:58:21 GMT 2023` Edited by `admin` on `Sat Dec 16 17:58:21 GMT 2023`
Record UNII	P712T71Q3T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MONOPHOSPHOTHIAMINE

Official Name

English

THIAMINE PHOSPHORIC ACID ESTER CHLORIDE

Common Name

English

NOVOBETA

Brand Name

English

THIAMINE MONOPHOSPHATE [MI]

Common Name

English

SUPERNEURINA

Brand Name

English

THIAMINE MONOPHOSPHATE CHLORIDE

Common Name

English

Monophosphothiamine [WHO-DD]

Common Name

English

THIAMINE MONOPHOSPHATE

Common Name

English

NOVANEURINA

Brand Name

English

FOSBIONE

Brand Name

English

THIAZOLIUM, 3-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)-4-METHYL-5-(2-(PHOSPHONOOXY)ETHYL)-, CHLORIDE (1:1)

Systematic Name

English

SINEURINA

Brand Name

English

monophosphothiamine [INN]

Common Name

English

PHOSPHOTHIAMINE

Common Name

English

TMP (THIAMINE ESTER)

Common Name

English

PHOSBITAMIN

Brand Name

English

PHOSPHOTHIAMIN

Common Name

English

VITAMIN B1 MONOPHOSPHATE CHLORIDE

Common Name

English

NEURIFOSFORIL

Brand Name

English

EXTRANEURINA

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C26017