PERFLUORODODECANOIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12HF23O2
Molecular Weight	614.0984
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

InChI

InChIKey=CXGONMQFMIYUJR-UHFFFAOYSA-N

InChI=1S/C12HF23O2/c13-2(14,1(36)37)3(15,16)4(17,18)5(19,20)6(21,22)7(23,24)8(25,26)9(27,28)10(29,30)11(31,32)12(33,34)35/h(H,36,37)

HIDE SMILES / InChI

Molecular Formula	C12HF23O2
Molecular Weight	614.0984
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Increased bilirubin and uroporphyrinogen oxidation in vitro.	2003 Aug 1	12907239
Isolating isomers of perfluorocarboxylates in polar bears (Ursus maritimus) from two geographical locations.	2004 Dec 15	15669310
Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries.	2004 Sep 1	15461154
Alkaline digestion and solid phase extraction method for perfluorinated compounds in mussels and oysters from South China and Japan.	2006 Feb	16170448
Perfluorooctanesulfonate and related fluorochemicals in human blood samples from China.	2006 Feb 1	16509308
Perfluorinated compounds in the Pearl River and Yangtze River of China.	2007 Aug	17368725
Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid.	2007 Jul	17400581
Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000.	2007 Nov	18007991
Emissions of perfluorinated alkylated substances (PFAS) from point sources--identification of relevant branches.	2008	18653937
Purification and thermal analysis of perfluoro-n-alkanoic acids.	2008 Jan 15	17719754
Time trends and transplacental transfer of perfluorinated compounds in melon-headed whales stranded along the Japanese coast in 1982, 2001/2002, and 2006.	2008 Oct 1	18939537
Occurrence and sources of perfluorinated surfactants in rivers in Japan.	2008 Sep 1	18800531
Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver.	2008 Sep 29	18760846
Occurrence of perfluoroalkyl carboxylates and sulfonates in drinking water utilities and related waters from the United States.	2009 Dec 15	20000497
Evaluation of wastewater and street runoff as sources of perfluorinated surfactants (PFSs).	2009 Jan	19054542
Fluorescence study on site-specific binding of perfluoroalkyl acids to human serum albumin.	2009 Mar	18854981
Determination of ten perfluorinated compounds in bluegill sunfish (Lepomis macrochirus) fillets.	2009 Nov	19775685
Perfluorinated compounds in sediments from the Daliao River system of northeast China.	2009 Oct	19735931
Perfluorododecanoic acid-induced steroidogenic inhibition is associated with steroidogenic acute regulatory protein and reactive oxygen species in cAMP-stimulated Leydig cells.	2010 Apr	20100736
Metabolic changes reveal the development of schistosomiasis in mice.	2010 Aug 31	20824219
Binding of perfluorocarboxylates to serum albumin: a comparison of analytical methods.	2010 Feb 1	20039637
Proteomic analysis for testis of rats chronically exposed to perfluorododecanoic acid.	2010 Feb 1	19854247
Perfluorinated compounds in urban river sediments from Guangzhou and Shanghai of China.	2010 Jun	20430414
Perfluorinated compounds, polychlorinated biphenyls, and organochlorine pesticide contamination in composite food samples from Dallas, Texas, USA.	2010 Jun	20146964
Chitosan-coated octadecyl-functionalized magnetite nanoparticles: preparation and application in extraction of trace pollutants from environmental water samples.	2010 Mar 15	20155948
Concentrations, distribution, and persistence of perfluoroalkylates in sludge-applied soils near Decatur, Alabama, USA.	2010 Nov 15	20949951
Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro.	2011 Mar	21163906
Transcriptional effects of perfluorinated compounds in rat hepatoma cells.	2012 Jan	22071372
Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): further investigation of C4-C12 compounds.	2012 Jul	22107727
In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths.	2013 Apr 12	23391484
Evaluation of perfluoroalkyl acid activity using primary mouse and human hepatocytes.	2013 Jun 7	23567314
Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity.	2013 Mar 27	23353032
Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ.	2014 Sep 15	24998974
Structure-activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor.	2015 Feb	24819616
Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver.	2016 Jun	26168851

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:03:33 GMT 2023` Edited by `admin` on `Sat Dec 16 09:03:33 GMT 2023`
Record UNII	P6G1J7NM2D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PERFLUORODODECANOIC ACID

Systematic Name

English

PERFLUOROLAURIC ACID

Systematic Name

English

PFDODA

Common Name

English

DODECANOIC ACID, TRICOSAFLUORO-

Systematic Name

English

DODECANOIC ACID, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-TRICOSAFLUORO-

Systematic Name

English

2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-TRICOSAFLUORODODECANOIC ACID

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID8031861