Aldastotug

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 16:17:21 GMT 2025` Edited by `admin` on `Wed Apr 02 16:17:21 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	P63Y458LB9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PYX-106

Preferred Name

English

Aldastotug

Official Name

English

Immunoglobulin G1, anti-(human sialic acid-binding Ig-like lectin 15) (human monoclonal PYX-106 ?1-chain), disulfide with human monoclonal PYX-106 ?-chain, dimer

Common Name

English

H-gamma1 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV5-10-1*01 (95.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.12](26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (216) (120-217), hinge 1-15

Common Name

English

aldastotug [INN]

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens SIGLEC15 (sialic acid-binding Ig-like lectin 15, CD33-like 3, CD33L3)], Homo sapiens monoclonal antibody

Common Name

English

Code System Code Type Description

INN

13002

Created by admin on Wed Apr 02 16:17:21 GMT 2025 , Edited by admin on Wed Apr 02 16:17:21 GMT 2025

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CAS

2865844-59-1

Created by admin on Wed Apr 02 16:17:21 GMT 2025 , Edited by admin on Wed Apr 02 16:17:21 GMT 2025

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FDA UNII

P63Y458LB9

Created by admin on Wed Apr 02 16:17:21 GMT 2025 , Edited by admin on Wed Apr 02 16:17:21 GMT 2025

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SMS_ID

300000047941

Created by admin on Wed Apr 02 16:17:21 GMT 2025 , Edited by admin on Wed Apr 02 16:17:21 GMT 2025

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NCI_THESAURUS

C199372

Created by admin on Wed Apr 02 16:17:21 GMT 2025 , Edited by admin on Wed Apr 02 16:17:21 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_146	2_202
2_222	4_215
2_263	2_323
1_146	1_202
2_369	2_427
3_23	3_89
3_135	3_195
4_23	4_89
4_135	4_195
1_222	3_215
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427

Glycosylation Link Type	Site
N	1_59
N	1_299
N	2_59
N	2_299

Related Record Type Details


					P63Y458LB9

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[3_1] [4_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_449] [2_449]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL