Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H10O6 |
| Molecular Weight | 286.2363 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C(O)=C3O
InChI
InChIKey=JVXZRQGOGOXCEC-UHFFFAOYSA-N
InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H
| Molecular Formula | C15H10O6 |
| Molecular Weight | 286.2363 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. | 2011-05-01 |
|
| [Absorption and transportation characteristics of scutellarin and scutellarein across Caco-2 monolayer model]. | 2010-09 |
|
| Comprehensive review of Clerodendrum phlomidis: a traditionally used bitter. | 2010-06 |
|
| Apoptotic effects of chrysin in human cancer cell lines. | 2010-05-19 |
|
| Anticancer drugs from marine flora: an overview. | 2010 |
|
| [Advances in studies on pharmacokinetics of scutellarin and scutellarein]. | 2009-12 |
|
| CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells. | 2009-10-29 |
|
| Inhibitory effect of flavonoids on 26S proteasome activity. | 2009-10-28 |
|
| Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. | 2009-03-25 |
|
| Qualitative evaluation and quantitative determination of 10 major active components in Carthamus tinctorius L. by high-performance liquid chromatography coupled with diode array detector. | 2009-03-13 |
|
| Mechanism of CYP2C9 inhibition by flavones and flavonols. | 2009-03 |
|
| The constituents of Anisomeles indica and their anti-inflammatory activities. | 2009-01-21 |
|
| In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids. | 2009-01 |
|
| Antioxidant activities of polyphenols extracted from Perilla frutescens varieties. | 2008-12-31 |
|
| Scutellarein inhibits hypoxia- and moderately-high glucose-induced proliferation and VEGF expression in human retinal endothelial cells. | 2008-06 |
|
| Inhibitory effect of Erigeron breviscapus extract and its flavonoid components on GABA shunt enzymes. | 2008-01 |
|
| Metabolites of scutellarein in rat plasma. | 2007-12-07 |
|
| Isolation and identification of ten metabolites of breviscapine in rat urine. | 2007-07 |
|
| Two major urinary metabolites of scutellarin in rats. | 2007-04 |
|
| Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase. | 2007-01-29 |
|
| [Study on bile excretion of scutellarein]. | 2006-10 |
|
| Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration. | 2006-08 |
|
| Determination of aglycone conjugated metabolites of scutellarin in rat plasma by HPLC. | 2006-02-13 |
|
| Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds. | 2006-01 |
|
| Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005-10-31 |
|
| Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats. | 2005-10-28 |
|
| Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. | 2005-10-19 |
|
| Validation of an HPLC method for the determination of scutellarin in rat plasma and its pharmacokinetics. | 2005-06-15 |
|
| Antioxidant activity of citrus limonoids, flavonoids, and coumarins. | 2005-03-23 |
|
| Separation of flavonoids from the seeds of Vernonia anthelmintica Willd by high-speed counter-current chromatography. | 2004-09-17 |
|
| Antagonistic effect of scutellarin on the toxicity of selenium in rat livers. | 2004-06 |
|
| Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin. | 2004-04-30 |
|
| [Determination of scutellarin and rutin in Shenfukang capsules by reversed-phase high performance liquid chromatography]. | 2004-03 |
|
| Metabolism of apigenin by rat liver phase I and phase ii enzymes and by isolated perfused rat liver. | 2004-01 |
|
| Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR. | 2003-12 |
|
| Protective effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes. | 2003-11 |
|
| Study on pharmacokinetics of scutellarin in rabbits. | 2003-10 |
|
| Variations in lipophilic and vacuolar flavonoids among European Pulicaria species. | 2003-09 |
|
| Identification of lipophilic flavones and flavonols by comparative HPLC, TLC and UV spectral analysis. | 2003-04-16 |
|
| Antioxidant flavonoids from leaves of Polygonum hydropiper L. | 2003-01 |
|
| [Recognition of three classes of skullcaps by FTIR spectroscopy combined with artificial neural networks]. | 2002-12 |
|
| Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex. | 2002-12 |
|
| Scutellarein 4'-methyl ether glycosides as taxonomic markers in Teucridium and Tripora (Lamiaceae, Ajugoideae). | 2002-08 |
|
| [Study on effects of scutellarin on scavenging reactive oxygen]. | 2002-07 |
|
| Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats. | 2002-03 |
|
| Antiviral Chinese medicinal herbs against respiratory syncytial virus. | 2002-02 |
|
| Inhibitory activity of flavonoids and tannins against HIV-1 protease. | 2000-09 |
|
| Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996-01-01 |
|
| Inhibition of HIV infection by flavanoids. | 1993-10 |
|
| Inhibition of reverse transcriptases by flavonoids. | 1989-09 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:13:22 GMT 2025
by
admin
on
Mon Mar 31 21:13:22 GMT 2025
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| Record UNII |
P460GTI853
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| Record Status |
Validated (UNII)
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| Record Version |
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100000175825
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DTXSID40200946
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SCUTELLAREIN
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m9819
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P460GTI853
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529-53-3
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| Related Record | Type | Details | ||
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PARENT -> ACTIVE CONSTITUENT ALWAYS PRESENT |
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| Related Record | Type | Details | ||
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PARENT -> METABOLITE |
