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Details

Stereochemistry ACHIRAL
Molecular Formula C15H10O6
Molecular Weight 286.2369
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SCUTELLAREIN

SMILES

c1cc(ccc1-c2cc(=O)c3c(cc(c(c3O)O)O)o2)O

InChI

InChIKey=JVXZRQGOGOXCEC-UHFFFAOYSA-N
InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H

HIDE SMILES / InChI

Molecular Formula C15H10O6
Molecular Weight 286.2369
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Inhibition of reverse transcriptases by flavonoids.
1989 Sep
Inhibition of HIV infection by flavanoids.
1993 Oct
Inhibition of HIV activation in latently infected cells by flavonoid compounds.
1996 Jan 1
Inhibitory activity of flavonoids and tannins against HIV-1 protease.
2000 Sep
Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex.
2002 Dec
Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR.
2003 Dec
Protective effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes.
2003 Nov
Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats.
2005 Jul-Sep
Validation of an HPLC method for the determination of scutellarin in rat plasma and its pharmacokinetics.
2005 Jun 15
Antioxidant activity of citrus limonoids, flavonoids, and coumarins.
2005 Mar 23
Molecular targets of dietary polyphenols with anti-inflammatory properties.
2005 Oct 31
Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration.
2006 Aug
Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds.
2006 Jan
[Study on bile excretion of scutellarein].
2006 Oct
Two major urinary metabolites of scutellarin in rats.
2007 Apr
Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase.
2007 Jan 29
Isolation and identification of ten metabolites of breviscapine in rat urine.
2007 Jul
Antioxidant activities of polyphenols extracted from Perilla frutescens varieties.
2008 Dec 31
Inhibitory effect of Erigeron breviscapus extract and its flavonoid components on GABA shunt enzymes.
2008 Jan
Metabolites of scutellarein in rat plasma.
2008 Jan-Feb
Scutellarein inhibits hypoxia- and moderately-high glucose-induced proliferation and VEGF expression in human retinal endothelial cells.
2008 Jun
[Advances in studies on pharmacokinetics of scutellarin and scutellarein].
2009 Dec
In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids.
2009 Jan
The constituents of Anisomeles indica and their anti-inflammatory activities.
2009 Jan 21
Mechanism of CYP2C9 inhibition by flavones and flavonols.
2009 Mar
Qualitative evaluation and quantitative determination of 10 major active components in Carthamus tinctorius L. by high-performance liquid chromatography coupled with diode array detector.
2009 Mar 13
Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
2009 Mar 25
Inhibitory effect of flavonoids on 26S proteasome activity.
2009 Oct 28
CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells.
2009 Oct 29
Anticancer drugs from marine flora: an overview.
2010
Comprehensive review of Clerodendrum phlomidis: a traditionally used bitter.
2010 Jun
Apoptotic effects of chrysin in human cancer cell lines.
2010 May 19
[Absorption and transportation characteristics of scutellarin and scutellarein across Caco-2 monolayer model].
2010 Sep
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
2011 May 1
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 10:03:30 UTC 2021
Edited
by admin
on Sat Jun 26 10:03:30 UTC 2021
Record UNII
P460GTI853
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SCUTELLAREIN
MI   WHO-DD  
Common Name English
5,6,7-TRIHYDROXY-2-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE
Systematic Name English
6-HYDROXYAPIGENIN
Common Name English
6-HYDROXYPELARGIDENON-1465
Common Name English
SCUTELLAREIN [MI]
Common Name English
SCUTELLAREIN [WHO-DD]
Common Name English
4',5,6,7-TETRAHYDROXYFLAVONE
Systematic Name English
AGLYCONE
Common Name English
Code System Code Type Description
EPA CompTox
529-53-3
Created by admin on Sat Jun 26 10:03:30 UTC 2021 , Edited by admin on Sat Jun 26 10:03:30 UTC 2021
PRIMARY
WIKIPEDIA
SCUTELLAREIN
Created by admin on Sat Jun 26 10:03:30 UTC 2021 , Edited by admin on Sat Jun 26 10:03:30 UTC 2021
PRIMARY
PUBCHEM
5281697
Created by admin on Sat Jun 26 10:03:30 UTC 2021 , Edited by admin on Sat Jun 26 10:03:30 UTC 2021
PRIMARY
MERCK INDEX
M9819
Created by admin on Sat Jun 26 10:03:30 UTC 2021 , Edited by admin on Sat Jun 26 10:03:30 UTC 2021
PRIMARY Merck Index
FDA UNII
P460GTI853
Created by admin on Sat Jun 26 10:03:30 UTC 2021 , Edited by admin on Sat Jun 26 10:03:30 UTC 2021
PRIMARY
CAS
529-53-3
Created by admin on Sat Jun 26 10:03:30 UTC 2021 , Edited by admin on Sat Jun 26 10:03:30 UTC 2021
PRIMARY
Related Record Type Details
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