U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 19:29:23 UTC 2023
Edited
by admin
on Sat Dec 16 19:29:23 UTC 2023
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE GENETICALLY MODIFIED
Organism Family Poxviridae
Organism Genus Orthopoxvirus
Organism Species vaccinia virus
Infraspecific Type RECOMBINANT VECTOR
Infraspecific Name VACV; strain Copenhagen-encoding three codon-optimised transgenes (CTLA-4/FLT3L/IL-12A, p35)
Part whole
Record UNII
P3D8R5LG7H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Raxorulimogene Belzovacirepvec
INN  
Official Name English
recombinant replication-competent oncolytic vaccinia virus (VACV; strain Copenhagen) encoding three codon-optimised transgenes: (i) anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) immunoglobulin G1 γ1-chain fused via a synthetic T2A peptide wi
Common Name English
raxorulimogene belzovacirepvec [INN]
Common Name English
Code System Code Type Description
FDA UNII
P3D8R5LG7H
Created by admin on Sat Dec 16 19:29:24 UTC 2023 , Edited by admin on Sat Dec 16 19:29:24 UTC 2023
PRIMARY
INN
12356
Created by admin on Sat Dec 16 19:29:24 UTC 2023 , Edited by admin on Sat Dec 16 19:29:24 UTC 2023
PRIMARY
CAS
2648343-10-4
Created by admin on Sat Dec 16 19:29:24 UTC 2023 , Edited by admin on Sat Dec 16 19:29:24 UTC 2023
PRIMARY
Related Record Type Details
EXPRESSED PROTEIN->VECTOR
EXPRESSED PROTEIN->VECTOR
EXPRESSED PROTEIN->VECTOR
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
GENE ADDITION Raxorulimogene belzovacirepvec transgene FLT3L AQD7H22H8U
GENE ADDITION Raxorulimogene belzovacirepvec transgene (IgGL–T2A-αCTLA4-IgGH) 63SFS9Q5ZB
GENE ADDITION Raxorulimogene belzovacirepvec transgene IL-12p35 7GAS5DQ2ZY