Raxorulimogene Belzovacirepvec

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 16:03:14 GMT 2025` Edited by `admin` on `Wed Apr 02 16:03:14 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	RECOMBINANT VIRUS
Source Materials State	LIVE GENETICALLY MODIFIED
Organism Family	Poxviridae
Organism Genus	Orthopoxvirus
Organism Species	vaccinia virus
Infraspecific Type	RECOMBINANT VECTOR
Infraspecific Name	VACV; strain Copenhagen-encoding three codon-optimised transgenes (CTLA-4/FLT3L/IL-12A, p35)
Part	whole
Record UNII	P3D8R5LG7H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Raxorulimogene Belzovacirepvec

Official Name

English

raxorulimogene belzovacirepvec [INN]

Preferred Name

English

recombinant replication-competent oncolytic vaccinia virus (VACV; strain Copenhagen) encoding three codon-optimised transgenes: (i) anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) immunoglobulin G1 ?1-chain fused via a synthetic T2A peptide wit

Common Name

English

Code System Code Type Description

FDA UNII

P3D8R5LG7H

Created by admin on Wed Apr 02 16:03:14 GMT 2025 , Edited by admin on Wed Apr 02 16:03:14 GMT 2025

PRIMARY

INN

12356

Created by admin on Wed Apr 02 16:03:14 GMT 2025 , Edited by admin on Wed Apr 02 16:03:14 GMT 2025

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SMS_ID

300000051848

Created by admin on Wed Apr 02 16:03:14 GMT 2025 , Edited by admin on Wed Apr 02 16:03:14 GMT 2025

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NCI_THESAURUS

C203114

Created by admin on Wed Apr 02 16:03:14 GMT 2025 , Edited by admin on Wed Apr 02 16:03:14 GMT 2025

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CAS

2648343-10-4

Created by admin on Wed Apr 02 16:03:14 GMT 2025 , Edited by admin on Wed Apr 02 16:03:14 GMT 2025

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Related Record Type Details


					6C38KUE2XK

Raxorulimogene belzovacirepvec expressed IL-12p35

EXPRESSED PROTEIN->VECTOR

Amount:


					Z7K8WVV2H3

Raxorulimogene belzovacirepvec expressed IgGL–T2A-?CTLA4-IgGH

EXPRESSED PROTEIN->VECTOR

Amount:


					52WL2V88MN

Raxorulimogene belzovacirepvec expressed FLT3L

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					P3D8R5LG7H

Raxorulimogene Belzovacirepvec

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
GENE ADDITION					Raxorulimogene belzovacirepvec transgene FLT3L	AQD7H22H8U
GENE ADDITION					Raxorulimogene belzovacirepvec transgene (IgGL–T2A-?CTLA4-IgGH)	63SFS9Q5ZB
GENE ADDITION					Raxorulimogene belzovacirepvec transgene IL-12p35	7GAS5DQ2ZY