Evazarsen

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 14:18:06 UTC 2023` Edited by `admin` on `Sat Dec 16 14:18:06 UTC 2023`
Nucleic Acid Subtype
Record UNII	P048YHG804
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Evazarsen

Official Name

English

DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RA-A-M5C-A-A-G-M5C-T-G-G-T-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RG-(

Systematic Name

English

ISIS-757456

Code

English

ISIS-654472 5'-GALNAC CONJUGATE

Code

English

evazarsen [INN]

Common Name

English

ALL-P-AMBO-5'-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXYL))PHOSPHO)-2'-O-(2-METHOXYETHYL)-5-METHYL-P-THIOCYTIDYLYL-(3'-O->5'-O)-2'-O-(2-METHOXYETHYL)-P-THIOAD

Systematic Name

English

EVAZARSEN [USAN]

Common Name

English

Code System Code Type Description

FDA UNII

P048YHG804

Created by admin on Sat Dec 16 14:18:06 UTC 2023 , Edited by admin on Sat Dec 16 14:18:06 UTC 2023

PRIMARY

INN

12355

Created by admin on Sat Dec 16 14:18:06 UTC 2023 , Edited by admin on Sat Dec 16 14:18:06 UTC 2023

PRIMARY

USAN

JK-205

Created by admin on Sat Dec 16 14:18:06 UTC 2023 , Edited by admin on Sat Dec 16 14:18:06 UTC 2023

PRIMARY

CAS

2589926-22-5

Created by admin on Sat Dec 16 14:18:06 UTC 2023 , Edited by admin on Sat Dec 16 14:18:06 UTC 2023

PRIMARY

NCI_THESAURUS

C188610

Created by admin on Sat Dec 16 14:18:06 UTC 2023 , Edited by admin on Sat Dec 16 14:18:06 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20
Deoxyribose (DNA)	1_6-1_15	10 / 20

Linkage	Site Range	Site Count
Phosporothioate	1_1-1_20	20 / 19

Related Record Type Details


					W3077QR2KG

EVAZARSEN SODIUM

SALT/SOLVATE -> PARENT

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_7] [1_11]	SITE_SPECIFIC			5-METHYLDEOXYCYTIDINE	B200GV71QM
NUCLEOSIDE_SUBSTITUTION	[1_19] [1_20]	SITE_SPECIFIC			2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE	9Q36I4D9VB
NUCLEOSIDE_SUBSTITUTION	[1_3] [1_16]	SITE_SPECIFIC			2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE	AOQ54IZZ6J
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			ISIS-757456 CYTOSINE PHOSPHATE 5'-MODIFICATION	49G0W4AL3R