PEGVORHYALURONIDASE ALFA

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:56:02 GMT 2025` Edited by `admin` on `Tue Apr 01 23:56:02 GMT 2025`
Protein Type	ENZYME
Protein Sub Type	PEGYLATED PROTEIN
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	P01I4980ZS
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PEGVORHYALURONIDASE ALFA

Official Name

English

PEGPH-20

Preferred Name

English

PEGVORHYALURONIDASE ALFA [USAN]

Common Name

English

POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-(3-CARBOXYPROPYL)-.OMEGA.-METHOXY-, AMIDE WITH HYALURONOGLUCOSAMINIDASE (HUMAN ISOENZYME PH20)

Common Name

English

Pegvorhyaluronidase alfa [WHO-DD]

Common Name

English

PEGPH20

Code

English

pegvorhyaluronidase alfa [INN]

Common Name

English

HUMAN HYALURONIDASE PH-20 (HYALURONOGLUCOSAMINIDASE PH-20, SPERM ADHESION MOLECULE 1, EC 3.2.1.35) PRECURSOR-(36-482)-PEPTIDE (MATURE (1-447)-PEPTIDE), PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, GLYCOFORM ALFA, SUBSTITUTED ON N6 OF AN AVERAGE OF 4 TO

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

447914

Created by admin on Tue Apr 01 23:56:02 GMT 2025 , Edited by admin on Tue Apr 01 23:56:02 GMT 2025

Code System Code Type Description

INN

10376

Created by admin on Tue Apr 01 23:56:02 GMT 2025 , Edited by admin on Tue Apr 01 23:56:02 GMT 2025

PRIMARY

NCI_THESAURUS

C82659

Created by admin on Tue Apr 01 23:56:02 GMT 2025 , Edited by admin on Tue Apr 01 23:56:02 GMT 2025

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SMS_ID

100000174564

Created by admin on Tue Apr 01 23:56:02 GMT 2025 , Edited by admin on Tue Apr 01 23:56:02 GMT 2025

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DRUG BANK

DB14912

Created by admin on Tue Apr 01 23:56:02 GMT 2025 , Edited by admin on Tue Apr 01 23:56:02 GMT 2025

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FDA UNII

P01I4980ZS

Created by admin on Tue Apr 01 23:56:02 GMT 2025 , Edited by admin on Tue Apr 01 23:56:02 GMT 2025

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PUBCHEM

121488170

Created by admin on Tue Apr 01 23:56:02 GMT 2025 , Edited by admin on Tue Apr 01 23:56:02 GMT 2025

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CAS

1620390-06-8

Created by admin on Tue Apr 01 23:56:02 GMT 2025 , Edited by admin on Tue Apr 01 23:56:02 GMT 2025

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USAN

EF-01

Created by admin on Tue Apr 01 23:56:02 GMT 2025 , Edited by admin on Tue Apr 01 23:56:02 GMT 2025

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From	To
1_25	1_316
1_189	1_203
1_341	1_352
1_346	1_400
1_402	1_408
1_423	1_429

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_47
N	1_131
N	1_200
N	1_219
N	1_333
N	1_358

Related Record Type Details


					P01I4980ZS

PEGVORHYALURONIDASE ALFA

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_1]	N-TERMINUS	L	Amount:	MPEG-LEUCINE (30000 MW)	EQ1R1O5LQ1
AMINO ACID SUBSTITUTION		RESIDUE_SPECIFIC	K	Amount:	MPEG 30000 BUTANOYL N6-LYSINE	87PSB2IP6M

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL