Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H10O2 |
Molecular Weight | 222.2387 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1C(=COC2=C1C=CC=C2)C3=CC=CC=C3
InChI
InChIKey=GOMNOOKGLZYEJT-UHFFFAOYSA-N
InChI=1S/C15H10O2/c16-15-12-8-4-5-9-14(12)17-10-13(15)11-6-2-1-3-7-11/h1-10H
Molecular Formula | C15H10O2 |
Molecular Weight | 222.2387 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Isoflavone, a type of phytoestrogen, is found in soy protein. It is a class of compound, substituted derivatives of isoflavone (e.g., genistein, daidzein, glycitein). Isoflavones exert antidiabetic and hypolipidemic effects by acting as peroxisome-proliferator activated receptors agonist. Isoflavones could participate in the regulation of adiposity and glucose metabolism. It was discovered, that isoflavone supplements prevented osteoporosis in women, by means of increasing bone mineral density and decreasing bone resorption marker urinary deoxypyridinoline.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q07869 Gene ID: 5465.0 Gene Symbol: PPARA Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/12730403 |
|||
Target ID: P37231|||Q15179 Gene ID: 5468.0 Gene Symbol: PPARG Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/12730403 |
PubMed
Title | Date | PubMed |
---|---|---|
Medicinal and ethnoveterinary remedies of hunters in Trinidad. | 2001 |
|
Cholesterol lowering benefits of soy and linseed enriched foods. | 2001 |
|
Suppression effect of soy isoflavones on nitric oxide production in RAW 264.7 macrophages. | 2001 Apr |
|
Improved methods for the extraction and analysis of isoflavones from soy-containing foods and nutritional supplements by reversed-phase high-performance liquid chromatography and liquid chromatography-mass spectrometry. | 2001 Apr 13 |
|
Inhibitory effects of licoisoflavones A and B and sophoraisoflavone A of Sophra mooracroftiana Beth ex Baker on copper-ion-induced protein oxidative modification of mice brain homogenate, in vitro. | 2001 Aug |
|
Isoflavone transformation during soybean koji preparation and subsequent miso fermentation supplemented with ethanol and NaCl. | 2001 Aug |
|
Early elicitor-induced events in chickpea cells: functional links between oxidative burst, sequential occurrence of extracellular alkalinisation and acidification, K+/H+ exchange and defence-related gene activation. | 2001 Jan-Feb |
|
Expression of neutrophil collagenase (MMP-8) in Jurkat T leukemia cells and its role in invasion. | 2001 Jan-Feb |
|
Estrogenic activity of two standardized red clover extracts (Menoflavon) intended for large scale use in hormone replacement therapy. | 2001 Jul |
|
Preparative separation of isoflavone components in soybeans using high-speed counter-current chromatography. | 2001 Jul 20 |
|
Changes in the profile of genistein, daidzein, and their conjugates during thermal processing of tofu. | 2001 Jun |
|
The vascular activity of some isoflavone metabolites: implications for a cardioprotective role. | 2001 Jun |
|
Lack of effect of isoflavonic phytoestrogen intake on leptin concentrations in premenopausal and postmenopausal women. | 2001 Jun |
|
Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes. | 2001 Jun 1 |
|
Soy isoflavone supplementation in postmenopausal women. Effects on plasma lipids, antioxidant enzyme activities and bone density. | 2001 Mar |
|
Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormones. | 2001 May |
|
[Infant formulas and soy protein-based formulas: current data]. | 2001 Nov |
|
High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. | 2001 Nov |
|
Novel lead generation through hypothetical pharmacophore three-dimensional database searching: discovery of isoflavonoids as nonsteroidal inhibitors of rat 5 alpha-reductase. | 2001 Nov 8 |
|
Effect of soy isoflavone supplementation on markers of oxidative stress in men and women. | 2001 Oct 22 |
|
Soy isoflavonoids and cancer -- metabolism at the target site. | 2001 Sep 1 |
|
Transplacental transfer of the phytoestrogen daidzein in DA/Han rats. | 2002 Feb |
|
Effects of the isoflavone 4',5,7-trihydroxyisoflavone (genistein) on psoralen plus ultraviolet A radiation (PUVA)-induced photodamage. | 2002 Feb |
|
A randomized isoflavone intervention among premenopausal women. | 2002 Feb |
|
The specific role of isoflavones on estrogen metabolism in premenopausal women. | 2002 Feb 15 |
|
Neurobehavioral effects of dietary soy phytoestrogens. | 2002 Jan-Feb |
|
Estrogenic isoflavones in rodent diets. | 2002 Mar 10 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22305793
in postmenopausal women: dose above 75 mg/d
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 07:42:38 GMT 2023
by
admin
on
Sat Dec 16 07:42:38 GMT 2023
|
Record UNII |
OVO2KUW8H8
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
100000125979
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY | |||
|
DTXSID90205986
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY | |||
|
SUB33145
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY | |||
|
C599
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY | |||
|
OVO2KUW8H8
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY | |||
|
m6489
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY | Merck Index | ||
|
135405
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY | |||
|
DB12007
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY | |||
|
72304
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY | |||
|
18220
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY | |||
|
574-12-9
Created by
admin on Sat Dec 16 07:42:38 GMT 2023 , Edited by admin on Sat Dec 16 07:42:38 GMT 2023
|
PRIMARY |