DIHYDRALAZINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H10N6.ClH
Molecular Weight	226.666
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DIHYDRALAZINE HYDROCHLORIDE

Structure Search

SMILES

Cl.NNC1=C2C=CC=CC2=C(NN)N=N1

InChI

InChIKey=IKVCCOSAYBITFB-UHFFFAOYSA-N

InChI=1S/C8H10N6.ClH/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7;/h1-4H,9-10H2,(H,11,13)(H,12,14);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C8H10N6
Molecular Weight	190.2052
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6477782

Dihydralazine is a compound with antihypertensive properties and is in clinical trials, where is studied its effect on kidney function and hormones in healthy individuals.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
High blood pressure 6 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6477782	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Rare liver damage caused by an antihypertensive and anti-arrhythmic agents].	1980 Apr 1	7405322
Action of vasodilating drugs on small and large arteries of hypertensive patients.	1983 Jul-Aug	6193361
[Liver lesions induced by dihydralazine and propranolol].	1985	3984541
Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.	1996 Oct-Nov	8902272
Influence of metabolic activation on the induction of micronuclei by antihypertensive drugs in L929 cells.	2001 Feb	11305783
[Hypertensive disorders in pregnancy].	2001 Feb 15	11253286
[When hypertension becomes an emergency case: lower the blood pressure, but slowly!].	2003 May 29	12866264
The impact of maternal plasma volume expansion and antihypertensive treatment with intravenous dihydralazine on fetal and maternal hemodynamics during pre-eclampsia: a clinical, echo-Doppler and viscometric study.	2004 Apr	15065180
Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against acrolein-mediated toxicity.	2004 Mar	14978244
Flow-injection chemiluminescence determination of dihydralazine sulfate based on hexacyanoferrate(III) oxidation sensitized by eosin Y.	2004 Oct 8	18969628
Isolated sarcoid granulomatous interstitial nephritis responding to infliximab therapy.	2005 Feb	15685521
Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.	2005 Mar	18360537
Evaluation of a strict protocol approach in managing women with severe disease due to hypertension in pregnancy: a before and after study.	2005 Sep 30	16197546
Antihypertensive therapy in patients with pre-eclampsia: A prospective randomised multicentre study comparing dihydralazine with urapidil.	2006 Aug	16253414
Nitric oxide-deficiency regulates hepatic heme oxygenase-1.	2008 Feb	17999922
Maternal and fetal hemodynamic effects induced by nitric oxide donors and plasma volume expansion in pregnancies with gestational hypertension complicated by intrauterine growth restriction with absent end-diastolic flow in the umbilical artery.	2008 Jan	18098350
Chemiluminescence investigation of carbon dioxide-enhanced oxidation of dihydralazine sulfate by peroxynitrite and its application to pharmaceutical analysis.	2008 Jun 2	18482603
Effects of dihydralazine on renal water and aquaporin-2 excretion in humans.	2009	18728933
[Drugs during preeclampsia. Fetal risks and pharmacology].	2010 Apr	20347563
Autoimmune hepatitis triggered by nitrofurantoin: a case series.	2010 Sep 23	20863377

Patents

Sample Use Guides

In Vivo Use Guide

The influence of a pure afterload reduction on systolic time intervals and various echocardiographic indices was assessed in six healthy volunteers, who underwent a single blind placebo controlled trial of three regimens of intravenous dihydralazine (6.25, 12.5, and 25.0 mg).

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:03:03 GMT 2023` Edited by `admin` on `Fri Dec 15 17:03:03 GMT 2023`
Record UNII	OVG1TP7A10
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DIHYDRALAZINE HYDROCHLORIDE

Common Name

English

1,4-PHTHALAZINEDIONE, 2,3-DIHYDRO-, DIHYDRAZONE, HYDROCHLORIDE (1:1)

Systematic Name

English

PHTHALAZINE, 1,4-DIHYDRAZINYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

Dihydralazine hydrochloride [WHO-DD]

Common Name

English

1,4-DIHYDRAZONO-1,2,3,4-TETRAHYDROPHTHALAZINE HYDROCHLORIDE (1:1)

Systematic Name

English

DIHYDRALAZINE HCL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270