Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H13ClF3N3O2 |
| Molecular Weight | 431.795 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)(F)C1=C(Cl)C=CC(NC(=O)NC2=CC(OC3=CC=C(C=C3)C#N)=CC=C2)=C1
InChI
InChIKey=QIBWSQJZKMUZAK-UHFFFAOYSA-N
InChI=1S/C21H13ClF3N3O2/c22-19-9-6-15(11-18(19)21(23,24)25)28-20(29)27-14-2-1-3-17(10-14)30-16-7-4-13(12-26)5-8-16/h1-11H,(H2,27,28,29)
| Molecular Formula | C21H13ClF3N3O2 |
| Molecular Weight | 431.795 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 18:04:18 GMT 2023
by
admin
on
Sat Dec 16 18:04:18 GMT 2023
|
| Record UNII |
OT4AQX5MLU
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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OT4AQX5MLU
Created by
admin on Sat Dec 16 18:04:18 GMT 2023 , Edited by admin on Sat Dec 16 18:04:18 GMT 2023
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300000005680
Created by
admin on Sat Dec 16 18:04:18 GMT 2023 , Edited by admin on Sat Dec 16 18:04:18 GMT 2023
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70688629
Created by
admin on Sat Dec 16 18:04:18 GMT 2023 , Edited by admin on Sat Dec 16 18:04:18 GMT 2023
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C156695
Created by
admin on Sat Dec 16 18:04:18 GMT 2023 , Edited by admin on Sat Dec 16 18:04:18 GMT 2023
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1400989-25-4
Created by
admin on Sat Dec 16 18:04:18 GMT 2023 , Edited by admin on Sat Dec 16 18:04:18 GMT 2023
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PRIMARY |
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Used a SHP-1 agonist SC-43 to dephosphorylate STAT3 thereby suppressing oncogenic STAT3 signaling and tested it in combination with docetaxel in TNBC cells
IN-VITRO
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ACTIVE MOIETY |
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