U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C21H13ClF3N3O2
Molecular Weight 431.795
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SC-43

SMILES

FC(F)(F)C1=C(Cl)C=CC(NC(=O)NC2=CC(OC3=CC=C(C=C3)C#N)=CC=C2)=C1

InChI

InChIKey=QIBWSQJZKMUZAK-UHFFFAOYSA-N
InChI=1S/C21H13ClF3N3O2/c22-19-9-6-15(11-18(19)21(23,24)25)28-20(29)27-14-2-1-3-17(10-14)30-16-7-4-13(12-26)5-8-16/h1-11H,(H2,27,28,29)

HIDE SMILES / InChI

Molecular Formula C21H13ClF3N3O2
Molecular Weight 431.795
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 18:04:18 GMT 2023
Edited
by admin
on Sat Dec 16 18:04:18 GMT 2023
Record UNII
OT4AQX5MLU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SC-43
Code English
UREA, N-(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)-N'-(3-(4-CYANOPHENOXY)PHENYL)-
Systematic Name English
N-(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)-N'-(3-(4-CYANOPHENOXY)PHENYL)UREA
Systematic Name English
SC 43
Code English
Code System Code Type Description
FDA UNII
OT4AQX5MLU
Created by admin on Sat Dec 16 18:04:18 GMT 2023 , Edited by admin on Sat Dec 16 18:04:18 GMT 2023
PRIMARY
SMS_ID
300000005680
Created by admin on Sat Dec 16 18:04:18 GMT 2023 , Edited by admin on Sat Dec 16 18:04:18 GMT 2023
PRIMARY
PUBCHEM
70688629
Created by admin on Sat Dec 16 18:04:18 GMT 2023 , Edited by admin on Sat Dec 16 18:04:18 GMT 2023
PRIMARY
NCI_THESAURUS
C156695
Created by admin on Sat Dec 16 18:04:18 GMT 2023 , Edited by admin on Sat Dec 16 18:04:18 GMT 2023
PRIMARY
CAS
1400989-25-4
Created by admin on Sat Dec 16 18:04:18 GMT 2023 , Edited by admin on Sat Dec 16 18:04:18 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> AGONIST
Used a SHP-​1 agonist SC-​43 to dephosphorylate STAT3 thereby suppressing oncogenic STAT3 signaling and tested it in combination with docetaxel in TNBC cells
IN-VITRO
Related Record Type Details
ACTIVE MOIETY