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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H14FN2O8P
Molecular Weight 340.1989
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PSI-7411

SMILES

C[C@@]1(F)[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N2C=CC(=O)NC2=O

InChI

InChIKey=JAJZLQMRDFLNSW-VPCXQMTMSA-N
InChI=1S/C10H14FN2O8P/c1-10(11)7(15)5(4-20-22(17,18)19)21-8(10)13-3-2-6(14)12-9(13)16/h2-3,5,7-8,15H,4H2,1H3,(H,12,14,16)(H2,17,18,19)/t5-,7-,8-,10-/m1/s1

HIDE SMILES / InChI
Molecular Formula C10H14FN2O8P
Molecular Weight 340.1989
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
SOVALDI

Approved Use

SOVALDI is a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor indicated for the treatment of chronic hepatitis C (CHC) infection as a component of a combination antiviral treatment regimen.

Launch Date

1.38620161E12
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:23:24 UTC 2023
Edited
by admin
on Sat Dec 16 08:23:24 UTC 2023
Record UNII
OOL8KAC85O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PSI-7411
Common Name English
GS-606965
Common Name English
((2R,3R,4R,5R)-5-(2,4-DIOXOPYRIMIDIN-1-YL)-4-FLUORO-3-HYDROXY-4-METHYL-TETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE
Systematic Name English
5'-URIDYLIC ACID, 2'-DEOXY-2'-FLUORO-2'-METHYL-, (2'R)-
Common Name English
Code System Code Type Description
FDA UNII
OOL8KAC85O
Created by admin on Sat Dec 16 08:23:24 UTC 2023 , Edited by admin on Sat Dec 16 08:23:24 UTC 2023
PRIMARY
EPA CompTox
DTXSID901319154
Created by admin on Sat Dec 16 08:23:24 UTC 2023 , Edited by admin on Sat Dec 16 08:23:24 UTC 2023
PRIMARY
PUBCHEM
23725126
Created by admin on Sat Dec 16 08:23:24 UTC 2023 , Edited by admin on Sat Dec 16 08:23:24 UTC 2023
PRIMARY
CAS
1015073-43-4
Created by admin on Sat Dec 16 08:23:24 UTC 2023 , Edited by admin on Sat Dec 16 08:23:24 UTC 2023
PRIMARY
Related Record Type Details
UMP-CMP KINASE
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
Structure of SOFOSBUVIR
PARENT -> METABOLITE
Structure of PSI-7976
PRODRUG -> METABOLITE ACTIVE
NIH
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