N-DESMETHYLTAMOXIFEN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H27NO
Molecular Weight	357.488
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC\C(=C(/C1=CC=CC=C1)C2=CC=C(OCCNC)C=C2)C3=CC=CC=C3

InChI

InChIKey=NYDCDZSEEAUOHN-IZHYLOQSSA-N

InChI=1S/C25H27NO/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2/h4-17,26H,3,18-19H2,1-2H3/b25-24-

HIDE SMILES / InChI

Molecular Formula	C25H27NO
Molecular Weight	357.488
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts.	1995 Mar	7697811
Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites.	2002 Oct	12419016
Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.	2003 Dec 3	14652237
Association of tamoxifen (TAM) and TAM metabolite concentrations with self-reported side effects of TAM in women with breast cancer.	2004 May	15039600
The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells.	2009 Mar 1	19244106

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:13:40 GMT 2023` Edited by `admin` on `Fri Dec 15 19:13:40 GMT 2023`
Record UNII	OOJ759O35C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-DESMETHYLTAMOXIFEN

Common Name

English

2-(4-((Z)-1,2-DIPHENYLBUT-1-ENYL)PHENOXY)-N-METHYLETHANAMINE

Systematic Name

English

DEMETHYLTAMOXIFEN

Common Name

English

ETHANAMINE, 2-(4-((1Z)-1,2-DIPHENYL-1-BUTEN-1-YL)PHENOXY)-N-METHYL-

Systematic Name

English

DESMETHYLTAMOXIFEN

Common Name

English

ICI-55548

Code

English

TAMOXIFEN CITRATE IMPURITY F [EP IMPURITY]

Common Name

English

DESMETHYLTAMOXIFEN, N-

Common Name

English

N-DEMETHYLTAMOXIFEN

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2163