Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H21N.ClH |
Molecular Weight | 191.741 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN1C(C)(C)CCCC1(C)C
InChI
InChIKey=OEAJJNMBFKSVHF-UHFFFAOYSA-N
InChI=1S/C10H21N.ClH/c1-9(2)7-6-8-10(3,4)11(9)5;/h6-8H2,1-5H3;1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C10H21N |
Molecular Weight | 155.2804 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/29010Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/13584741 | https://www.ncbi.nlm.nih.gov/pubmed/5994381 | https://www.ncbi.nlm.nih.gov/pubmed/13618559 | https://www.ncbi.nlm.nih.gov/pubmed/22290370
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29010
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/13584741 | https://www.ncbi.nlm.nih.gov/pubmed/5994381 | https://www.ncbi.nlm.nih.gov/pubmed/13618559 | https://www.ncbi.nlm.nih.gov/pubmed/22290370
Pempidine is a nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs. In preclinical models Pempidine blocks the effects of intravenous nicotine and of peripheral vagal stimulation on the blood pressure; it also causes dilatation of the pupil after removal of the sympathetic innervation. On the guinea-pig ileum, the predominant effect of the compound is to inhibit nicotine contractions. Pempidineis well absorbed from the gastrointestinal tract as judged by (a) the low ratio (6.9) of oral to intravenous toxicities, (b) the rapid development of mydriasis in mice after oral administration of small doses, and (c) the rapid onset of hypotension when the compound is injected directly into the duodenum of anaesthetized cats. Other actions include neuromuscular paralysis of curare-like type when large doses of the compound are injected intravenously and central effects such as tremors which occur with near toxic doses. In cats with a low blood pressure, large intravenous doses have a slight pressor action.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2362997 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2366189 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
[3H]benzylpempidine, a new radioligand for probing a putative channel site on nicotinic cholinergic receptors. | 1997 |
|
Spirocyclic zwitterionic lambda5Si-silicates with two bidentate ligands derived from alpha-amino acids or alpha-hydroxycarboxylic acids: synthesis, structure, and stereodynamics. | 2004 Nov 10 |
|
Corticosterone implants to the amygdala and type 1 CRH receptor regulation: effects on behavior and colonic sensitivity. | 2005 Jun 3 |
|
Magnetic "fishing" assay to screen small-molecule mixtures for modulators of protein-protein interactions. | 2010 Dec 1 |
|
Enantioselective synthesis of substituted indanones from silyloxyallenes. | 2010 Feb 10 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13618559
LD50 for the HCl salt of pempidine in mice: 74 mg/kg (i.v.); 125 mg/kg (i.p.); 413 mg/kg (p.o.).
Route of Administration:
Other
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 00:36:47 GMT 2023
by
admin
on
Sat Dec 16 00:36:47 GMT 2023
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Record UNII |
OL36S79I19
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Record Status |
Validated (UNII)
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Record Version |
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OL36S79I19
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ACTIVE MOIETY |