IERAMILIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:20:26 GMT 2025` Edited by `admin` on `Tue Apr 01 22:20:26 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	OI8P0SFD4R
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IERAMILIMAB

Official Name

English

LAG-525

Preferred Name

English

ieramilimab [INN]

Common Name

English

LAG525

Code

English

IERAMILIMAB [USAN]

Common Name

English

ANTI-LAG-3 MONOCLONAL ANTIBODY LAG525

Common Name

English

IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENS LAG3 (LYMPHOCYTE ACTIVATING 3, LYMPHOCYTE-ACTIVATION 3, CD223)), HUMANIZED MONOCLONAL ANTIBODY; GAMMA4 HEAVY CHAIN HUMANIZED (1-451) (VH (HOMO SAPIENS IGHV7-4-1*02 (85.7%)-(IGHD)-IGHJ4*01 (92.3%)) (8.8.18) (1-1

Common Name

English

HUMANISED IMP-701

Common Name

English

Ieramilimab [WHO-DD]

Common Name

English

NVP-LAG525

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C134305

Created by admin on Tue Apr 01 22:20:26 GMT 2025 , Edited by admin on Tue Apr 01 22:20:26 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C122683

Created by admin on Tue Apr 01 22:20:26 GMT 2025 , Edited by admin on Tue Apr 01 22:20:26 GMT 2025

PRIMARY

CAS

2072080-18-1

Created by admin on Tue Apr 01 22:20:26 GMT 2025 , Edited by admin on Tue Apr 01 22:20:26 GMT 2025

NO STRUCTURE GIVEN

WIKIPEDIA

Ieramilimab

Created by admin on Tue Apr 01 22:20:26 GMT 2025 , Edited by admin on Tue Apr 01 22:20:26 GMT 2025

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SMS_ID

100000183828

Created by admin on Tue Apr 01 22:20:26 GMT 2025 , Edited by admin on Tue Apr 01 22:20:26 GMT 2025

PRIMARY

FDA UNII

OI8P0SFD4R

Created by admin on Tue Apr 01 22:20:26 GMT 2025 , Edited by admin on Tue Apr 01 22:20:26 GMT 2025

PRIMARY

USAN

JK-98

Created by admin on Tue Apr 01 22:20:26 GMT 2025 , Edited by admin on Tue Apr 01 22:20:26 GMT 2025

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INN

11005

Created by admin on Tue Apr 01 22:20:26 GMT 2025 , Edited by admin on Tue Apr 01 22:20:26 GMT 2025

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CAS

2137049-37-5

Created by admin on Tue Apr 01 22:20:26 GMT 2025 , Edited by admin on Tue Apr 01 22:20:26 GMT 2025

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From	To
1_22	1_96
1_139	3_214
1_152	1_208
1_231	2_231
1_234	2_234
1_266	1_326
1_372	1_430
2_22	2_96
2_139	4_214
2_152	2_208
2_266	2_326
2_372	2_430
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_302
N	2_302

Related Record Type Details


					AK0JDV1ZK5

LYMPHOCYTE ACTIVATION GENE 3 PROTEIN

TARGET -> INHIBITOR

Related Record Type Details


					OI8P0SFD4R

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL