TOZORAKIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 05:14:16 GMT 2025` Edited by `admin` on `Wed Apr 02 05:14:16 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	OHZ2MEL7FD
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MEDI-3506

Preferred Name

English

TOZORAKIMAB

Official Name

English

MEDI3506

Code

English

TOZORAKIMAB [USAN]

Common Name

English

Immunoglobulin G1-lambda2, anti-[Homo sapiens IL33 (interleukin 33, DVS27, NF-HEV, IL1F11)], monoclonal antibody; gamma1 heavy chain (1-456) [VH (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ4*01 (85.7%) L123>M (121)) CDR-IMGT [8.8.19] (26-33.51-58.97-1

Common Name

English

Tozorakimab [WHO-DD]

Common Name

English

tozorakimab [INN]

Common Name

English

Immunoglobulin G1, anti-(human interleukin 33) (human monoclonal MEDI3506 ?1-chain), disulfide with human monoclonal MEDI3506 ?-chain, dimer

Common Name

English

Code System Code Type Description

INN

11647

Created by admin on Wed Apr 02 05:14:16 GMT 2025 , Edited by admin on Wed Apr 02 05:14:16 GMT 2025

PRIMARY

INN

USAN

KL-47

Created by admin on Wed Apr 02 05:14:16 GMT 2025 , Edited by admin on Wed Apr 02 05:14:16 GMT 2025

PRIMARY

NCI_THESAURUS

C179129

Created by admin on Wed Apr 02 05:14:16 GMT 2025 , Edited by admin on Wed Apr 02 05:14:16 GMT 2025

PRIMARY

CAS

2376858-66-9

Created by admin on Wed Apr 02 05:14:16 GMT 2025 , Edited by admin on Wed Apr 02 05:14:16 GMT 2025

PRIMARY

SMS_ID

300000003880

Created by admin on Wed Apr 02 05:14:16 GMT 2025 , Edited by admin on Wed Apr 02 05:14:16 GMT 2025

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FDA UNII

OHZ2MEL7FD

Created by admin on Wed Apr 02 05:14:16 GMT 2025 , Edited by admin on Wed Apr 02 05:14:16 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_153	2_209
2_229	4_211
2_270	2_330
1_153	1_209
2_376	2_434
3_22	3_87
3_134	3_193
4_22	4_87
4_134	4_193
1_229	3_211
1_235	2_235
1_238	2_238
1_270	1_330
1_376	1_434

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_306
N	2_306

Related Record Type Details


					L752D44I79

TARGET -> INHIBITOR

Amount:


					L752D44I79

TARGET->LIGAND

Amount:

Related Record Type Details


					OHZ2MEL7FD

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL		C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL