5-O-DESMETHYLNOBILETIN

COC1=C(OC)C=C(C=C1)C2=CC(=O)C3=C(O)C(OC)=C(OC)C(OC)=C3O2

InChIKey=DOFJNFPSMUCECH-UHFFFAOYSA-N

InChI=1S/C20H20O8/c1-23-12-7-6-10(8-14(12)24-2)13-9-11(21)15-16(22)18(25-3)20(27-5)19(26-4)17(15)28-13/h6-9,22H,1-5H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Apoptosis 155 Target ID: map04210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28154877\|https://www.ncbi.nlm.nih.gov/pubmed/25765513	Activator 1430
Non-small cell lung cancer 1 Target ID: map05223 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27219898	Inhibitor 8297
LDL receptor 1 Target ID: CHEMBL3311 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21225617	Activator 1430

PubMed

Title	Date	PubMed
Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells.	2005 Jan	15665459
Demethylnobiletin inhibits delayed-type hypersensitivity reactions, human lymphocyte proliferation and cytokine production.	2007 Dec	17934513
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.	2007 May 15	17391969
Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.	2009 Jan 1	19054677
[Reparative isolation and purification of flavones from Pericarpium Citri Reticulatae by high-speed counter-current chromatography].	2009 Mar	19626859
[Isolation and purification of flavones from Murraya exotica L. by high-speed counter-current chromatography].	2010 Apr	20712121
Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract.	2010 Aug-Sep	20538032
Simultaneous determination of four 5-hydroxy polymethoxyflavones by reversed-phase high performance liquid chromatography with electrochemical detection.	2010 Jan 29	20022018
Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells.	2010 Jul	20397199
Constituents of Calamintha ashei: effects on Florida sandhill species.	2010 May	20521531

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:44:29 UTC 2023` Edited by `admin` on `Fri Dec 15 18:44:29 UTC 2023`
Record UNII	OGE0V42MOT
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

5-O-DESMETHYLNOBILETIN

Common Name

English

5-O-DEMETHYLNOBILETIN

Common Name

English

4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIMETHOXYPHENYL)-5-HYDROXY-6,7,8-TRIMETHOXY-

Systematic Name

English

NSC-618927

Code

English

Code System Code Type Description

FDA UNII

OGE0V42MOT