5-O-DESMETHYLNOBILETIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H20O8
Molecular Weight	388.368
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1OC)C2=CC(=O)C3=C(O2)C(OC)=C(OC)C(OC)=C3O

InChI

InChIKey=DOFJNFPSMUCECH-UHFFFAOYSA-N

InChI=1S/C20H20O8/c1-23-12-7-6-10(8-14(12)24-2)13-9-11(21)15-16(22)18(25-3)20(27-5)19(26-4)17(15)28-13/h6-9,22H,1-5H3

HIDE SMILES / InChI

Molecular Formula	C20H20O8
Molecular Weight	388.368
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Apoptosis 156 Target ID: map04210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28154877\|https://www.ncbi.nlm.nih.gov/pubmed/25765513	Activator 1447
Non-small cell lung cancer 1 Target ID: map05223 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27219898	Inhibitor 8504
LDL receptor 1 Target ID: CHEMBL3311 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21225617	Activator 1447

PubMed

Title	Date	PubMed
Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells.	2010-07	20397199
Constituents of Calamintha ashei: effects on Florida sandhill species.	2010-05	20521531
[Isolation and purification of flavones from Murraya exotica L. by high-speed counter-current chromatography].	2010-04	20712121
Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract.	2010-03-20	20538032
Simultaneous determination of four 5-hydroxy polymethoxyflavones by reversed-phase high performance liquid chromatography with electrochemical detection.	2010-01-29	20022018
Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection.	2009-08-12	19722565
[Reparative isolation and purification of flavones from Pericarpium Citri Reticulatae by high-speed counter-current chromatography].	2009-03	19626859
Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.	2009-01-01	19054677
Demethylnobiletin inhibits delayed-type hypersensitivity reactions, human lymphocyte proliferation and cytokine production.	2007-12	17934513
Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.	2007-05-15	17391969
Preparative isolation and purification of polymethoxylated flavones from Tangerine peel using high-speed counter-current chromatography.	2005-10-07	16196149
Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells.	2005-01	15665459

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:19:42 GMT 2025` Edited by `admin` on `Mon Mar 31 19:19:42 GMT 2025`
Record UNII	OGE0V42MOT
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

5-O-DESMETHYLNOBILETIN

Common Name

English

NSC-618927

Preferred Name

English

5-O-DEMETHYLNOBILETIN

Common Name

English

4H-1-BENZOPYRAN-4-ONE, 2-(3,4-DIMETHOXYPHENYL)-5-HYDROXY-6,7,8-TRIMETHOXY-

Systematic Name

English

Code System Code Type Description

FDA UNII

OGE0V42MOT