Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C11H14N6.2ClH |
| Molecular Weight | 303.191 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.NC(=N)N\N=C1/CCC2=C(C=CC=C12)C(N)=N
InChI
InChIKey=UHEIPGJSFDAPIC-NENXIMLWSA-N
InChI=1S/C11H14N6.2ClH/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15;;/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17);2*1H/b16-9+;;
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C11H14N6 |
| Molecular Weight | 230.2691 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Sardomozide (previously known as SAM486A or CGP-48664) was developed as an inhibitor of S-adenosyl-methionine-decarboxylase, a key enzyme for polyamine biosynthesis. Sardomozide possessed the broad-spectrum antiproliferative and antitumor activity. The drug participated in a phase II clinical trial as a monotherapy in patients with refractory or relapsed non-Hodgkin's lymphoma. In Phase II clinical trial in patients with metastatic melanoma, the drug didn’t have significant therapeutic potential. The further development of this drug was discontinued.
Originator
Approval Year
Sample Use Guides
Forty-one previously treated patients with either diffuse large cell, follicular, or peripheral T-cell NHL were treated i.v. with 100 mg/m(2) SAM486A (SARDOMOZIDE) as a daily 1-h infusion for 5 days repeated every 3 weeks. Treatment was continued for a total of eight cycles or until disease progression.
Route of Administration:
Intravenous
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:26:35 GMT 2023
by
admin
on
Sat Dec 16 10:26:35 GMT 2023
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| Record UNII |
OEH39O5H7C
|
| Record Status |
Validated (UNII)
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| Record Version |
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OEH39O5H7C
Created by
admin on Sat Dec 16 10:26:35 GMT 2023 , Edited by admin on Sat Dec 16 10:26:35 GMT 2023
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10402702
Created by
admin on Sat Dec 16 10:26:35 GMT 2023 , Edited by admin on Sat Dec 16 10:26:35 GMT 2023
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138794-73-7
Created by
admin on Sat Dec 16 10:26:35 GMT 2023 , Edited by admin on Sat Dec 16 10:26:35 GMT 2023
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PARENT -> SALT/SOLVATE |
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