7-AMINO-4-METHYLCOUMARIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H9NO2
Molecular Weight	175.184
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(=O)OC2=C1C=CC(N)=C2

InChI

InChIKey=GLNDAGDHSLMOKX-UHFFFAOYSA-N

InChI=1S/C10H9NO2/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5H,11H2,1H3

HIDE SMILES / InChI

Molecular Formula	C10H9NO2
Molecular Weight	175.184
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
A time-resolved fluorescence probe for dipeptidyl peptidase 4 and its application in inhibitor screening.	2010-12-03	20938933
Low-lying excited states of C120 and C151: a multireference perturbation theory study.	2010-12-02	21049893
Förster's resonance energy transfer between Fullerene C60 and Coumarin C440.	2010-12	20869302
14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells.	2010-11-30	21118500
The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine.	2010-11-22	21092190
α-Chymotrypsin-catalyzed reaction confined in block-copolymer vesicles.	2010-11-15	20973117
Protein association and dissociation regulated by extension peptide: a mode for iron control by phytoferritin in seeds.	2010-11	20841455
Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties.	2010-10-27	21060878
Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors.	2010-09	20718745
Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts.	2010-08-05	20700487
An overview of caspase: Apoptotic protein for silicosis.	2010-08	21120077
Nature of action of Sitagliptin, the dipeptidyl peptidase-IV inhibitor in diabetic animals.	2010-08	20927248
Role of the ATM-checkpoint kinase 2 pathway in CDT-mediated apoptosis of gingival epithelial cells.	2010-07-23	20668524
Effect of noncompetitive proteasome inhibition on bortezomib resistance.	2010-07-21	20505154
Phosphorylation and methylation of proteasomal proteins of the haloarcheon Haloferax volcanii.	2010-07-08	20671954
IL-10 mediates rosiglitazone-induced kidney protection in cisplatin nephrotoxicity.	2010-04	20357998
Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines.	2010-03-23	20352108
Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.	2010-03-22	20339559
Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke.	2010-01-22	19941836
Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives.	2010-01	19837487
Eicosapentaenoic acid preserves diaphragm force generation following endotoxin administration.	2010	20233404
A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide.	2009-12-15	19682970
Capillary electrophoresis for screening of 20S proteasome inhibitors.	2009-11-01	19615965
A family of diverse Kunitz inhibitors from Echinococcus granulosus potentially involved in host-parasite cross-talk.	2009-09-17	19759914
Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity.	2009-09	19631386
A cellular model to monitor proteasome dysfunction by alpha-synuclein.	2009-08-25	19630439
FoxM1 is a general target for proteasome inhibitors.	2009-08-12	19672316
Bacillus cereus spores release alanine that synergizes with inosine to promote germination.	2009-07-28	19636427
Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys.	2009-07	19336678
A quantitative technique for determining proteases and their substrate specificities and pH optima in crude enzyme extracts.	2009-05-01	20334826
The proteasome is a molecular target of environmental toxic organotins.	2009-03	19337512
Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells.	2009-02-16	19216805
High-performance liquid chromatography determination of nitrated polycyclic aromatic hydrocarbons by indirect fluorescence detection.	2009-02	18816459
Characterization of bacterial proteases with a panel of fluorescent peptide substrates.	2009-01-15	18957278
Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like Peptide 1 infusion increases liver glucose uptake in the conscious dog.	2009-01	18840785
50 Hz extremely low frequency electromagnetic fields enhance protein carbonyl groups content in cancer cells: effects on proteasomal systems.	2009	19672456
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.	2008-11-29	19565019
Synthesis of novel substituted 7-(benzylideneamino)-4-methyl-2H-chromen-2-one derivatives as anti-inflammatory and analgesic agents.	2008-11	18973171
A parasite cysteine protease is key to host protein degradation and iron acquisition.	2008-10-24	18701454
Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor.	2008-09-24	18761452
Optimized conditions for high-performance liquid chromatography analysis of oligosaccharides using 7-amino-4-methylcoumarin as a reductive amination reagent.	2008-09-05	18684461
Development of a countergradient parking system for gradient liquid chromatography with online biochemical detection of serine protease inhibitors.	2008-09-01	18686973
Prodrugs of fluoro-substituted benzoates of EGC as tumor cellular proteasome inhibitors and apoptosis inducers.	2008-06	19325839
Identification of a new class of nonpeptidic inhibitors of cruzain.	2008-05-21	18435536
Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases.	2008-03-18	18348719
In situ and multisubstrate detection of elastase enzymatic activity external to microdialysis sampling probes using LC-ESI-MS.	2008-03-15	18278883
Synthesis and evaluation of anti-inflammatory and analgesic activities of a novel series of substituted-N-(4-methyl-2-oxo-2H-chromen-7-yl) benzamides.	2008	19202735
Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm.	2008	18786263
High-throughput screening of peptide deformylase inhibitors.	2008	18437310
Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts.	2007	18300387

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:10:57 GMT 2025` Edited by `admin` on `Mon Mar 31 19:10:57 GMT 2025`
Record UNII	OCY3JCT44X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-45796

Preferred Name

English

7-AMINO-4-METHYLCOUMARIN

Systematic Name

English

2H-1-BENZOPYRAN-2-ONE, 7-AMINO-4-METHYL-

Systematic Name

English

C 120

Common Name

English

7-AMINO-4-METHYL-2H-CHROMEN-2-ONE

Systematic Name

English

7-AMINO-4-METHYL-CHROMEN-2-ONE

Systematic Name

English

(4-METHYL-2-OXO-2H-CHROMEN-7-YL)AMINE

Systematic Name

English

7-AMC

Common Name

English

4-METHYL-7-AMINOCOUMARIN

Systematic Name

English

COUMARIN 120

Common Name

English

COUMARIN 440

Common Name

English

COUMARIN, 7-AMINO-4-METHYL-

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB08168