7-AMINO-4-METHYLCOUMARIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H9NO2
Molecular Weight	175.184
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(=O)OC2=C1C=CC(N)=C2

InChI

InChIKey=GLNDAGDHSLMOKX-UHFFFAOYSA-N

InChI=1S/C10H9NO2/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5H,11H2,1H3

HIDE SMILES / InChI

Molecular Formula	C10H9NO2
Molecular Weight	175.184
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts.	2007	18300387
Synthesis and evaluation of anti-inflammatory and analgesic activities of a novel series of substituted-N-(4-methyl-2-oxo-2H-chromen-7-yl) benzamides.	2008	19202735
Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm.	2008	18786263
High-throughput screening of peptide deformylase inhibitors.	2008	18437310
Prodrugs of fluoro-substituted benzoates of EGC as tumor cellular proteasome inhibitors and apoptosis inducers.	2008 Jun	19325839
In situ and multisubstrate detection of elastase enzymatic activity external to microdialysis sampling probes using LC-ESI-MS.	2008 Mar 15	18278883
Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases.	2008 Mar 18	18348719
Identification of a new class of nonpeptidic inhibitors of cruzain.	2008 May 21	18435536
Synthesis of novel substituted 7-(benzylideneamino)-4-methyl-2H-chromen-2-one derivatives as anti-inflammatory and analgesic agents.	2008 Nov	18973171
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.	2008 Nov 29	19565019
A parasite cysteine protease is key to host protein degradation and iron acquisition.	2008 Oct 24	18701454
Development of a countergradient parking system for gradient liquid chromatography with online biochemical detection of serine protease inhibitors.	2008 Sep 1	18686973
Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor.	2008 Sep 24	18761452
Optimized conditions for high-performance liquid chromatography analysis of oligosaccharides using 7-amino-4-methylcoumarin as a reductive amination reagent.	2008 Sep 5	18684461
50 Hz extremely low frequency electromagnetic fields enhance protein carbonyl groups content in cancer cells: effects on proteasomal systems.	2009	19672456
FoxM1 is a general target for proteasome inhibitors.	2009 Aug 12	19672316
A cellular model to monitor proteasome dysfunction by alpha-synuclein.	2009 Aug 25	19630439
A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide.	2009 Dec 15	19682970
High-performance liquid chromatography determination of nitrated polycyclic aromatic hydrocarbons by indirect fluorescence detection.	2009 Feb	18816459
Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells.	2009 Feb 16	19216805
Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like Peptide 1 infusion increases liver glucose uptake in the conscious dog.	2009 Jan	18840785
Characterization of bacterial proteases with a panel of fluorescent peptide substrates.	2009 Jan 15	18957278
Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys.	2009 Jul	19336678
Bacillus cereus spores release alanine that synergizes with inosine to promote germination.	2009 Jul 28	19636427
The proteasome is a molecular target of environmental toxic organotins.	2009 Mar	19337512
A quantitative technique for determining proteases and their substrate specificities and pH optima in crude enzyme extracts.	2009 May 1	20334826
Capillary electrophoresis for screening of 20S proteasome inhibitors.	2009 Nov 1	19615965
Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity.	2009 Sep	19631386
A family of diverse Kunitz inhibitors from Echinococcus granulosus potentially involved in host-parasite cross-talk.	2009 Sep 17	19759914
Eicosapentaenoic acid preserves diaphragm force generation following endotoxin administration.	2010	20233404
IL-10 mediates rosiglitazone-induced kidney protection in cisplatin nephrotoxicity.	2010 Apr	20357998
An overview of caspase: Apoptotic protein for silicosis.	2010 Aug	21120077
Nature of action of Sitagliptin, the dipeptidyl peptidase-IV inhibitor in diabetic animals.	2010 Aug	20927248
Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts.	2010 Aug 5	20700487
Förster's resonance energy transfer between Fullerene C60 and Coumarin C440.	2010 Dec	20869302
Low-lying excited states of C120 and C151: a multireference perturbation theory study.	2010 Dec 2	21049893
A time-resolved fluorescence probe for dipeptidyl peptidase 4 and its application in inhibitor screening.	2010 Dec 3	20938933
Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives.	2010 Jan	19837487
Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke.	2010 Jan 22	19941836
Effect of noncompetitive proteasome inhibition on bortezomib resistance.	2010 Jul 21	20505154
Role of the ATM-checkpoint kinase 2 pathway in CDT-mediated apoptosis of gingival epithelial cells.	2010 Jul 23	20668524
Phosphorylation and methylation of proteasomal proteins of the haloarcheon Haloferax volcanii.	2010 Jul 8	20671954
Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.	2010 Mar 22	20339559
Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines.	2010 Mar 23	20352108
Protein association and dissociation regulated by extension peptide: a mode for iron control by phytoferritin in seeds.	2010 Nov	20841455
α-Chymotrypsin-catalyzed reaction confined in block-copolymer vesicles.	2010 Nov 15	20973117
The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine.	2010 Nov 22	21092190
14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells.	2010 Nov 30	21118500
Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties.	2010 Oct 27	21060878
Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors.	2010 Sep	20718745

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:20:32 GMT 2023` Edited by `admin` on `Fri Dec 15 18:20:32 GMT 2023`
Record UNII	OCY3JCT44X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

7-AMINO-4-METHYLCOUMARIN

Systematic Name

English

2H-1-BENZOPYRAN-2-ONE, 7-AMINO-4-METHYL-

Systematic Name

English

C 120

Common Name

English

7-AMINO-4-METHYL-2H-CHROMEN-2-ONE

Systematic Name

English

7-AMINO-4-METHYL-CHROMEN-2-ONE

Systematic Name

English

(4-METHYL-2-OXO-2H-CHROMEN-7-YL)AMINE

Systematic Name

English

7-AMC

Common Name

English

4-METHYL-7-AMINOCOUMARIN

Systematic Name

English

NSC-45796

Code

English

COUMARIN 120

Common Name

English

COUMARIN 440

Common Name

English

COUMARIN, 7-AMINO-4-METHYL-

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB08168