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Details

Stereochemistry ACHIRAL
Molecular Formula 2C5H4NS.Zn
Molecular Weight 285.723
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINC 2-PYRIDINETHIOL

SMILES

[Zn++].[S-]C1=CC=CC=N1.[S-]C2=CC=CC=N2

InChI

InChIKey=PTRHHPOMKXGTAC-UHFFFAOYSA-L
InChI=1S/2C5H5NS.Zn/c2*7-5-3-1-2-4-6-5;/h2*1-4H,(H,6,7);/q;;+2/p-2

HIDE SMILES / InChI

Molecular Formula C5H5NS
Molecular Weight 111.165
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Zn
Molecular Weight 65.409
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Pyrithione zinc is an antibacterial and antifungal agent. Because of its antifungal properties, it is commonly found in dandruff shampoo. Products containing pyrithione zinc are available today with and without prescription, and it is the main ingredient in many over-the-counter creams, lotions, soaps, and shampoos. It also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera. Pyrithione zinc`s other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, atopic dermatitis, tinea, and vitiligo. It was shown that Pyrithione zinc inhibits fungal growth through increased cellular levels of copper, damaging iron-sulphur clusters of proteins essential for fungal metabolism.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Pyrithione zinc shampoo

Approved Use

Pyrithione zinc shampoo is used for: Treating and preventing itching, flaking, and scaling of the scalp caused by dandruff or seborrhea (oily, crusting, or scaling skin). Pyrithione zinc shampoo is an antiseborrheic. It works by slowing the production of skin cells, which helps to reduce flakiness.

Launch Date

1986
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

Shake well before each use. Wet hair thoroughly. Apply pyrithione zinc shampoo and work into a lather. Rinse thoroughly and repeat. For best results, use pyrithione zinc shampoo at least 2 times per week.
Route of Administration: Topical
Zinc pyrithione-induced cytotoxity in dermal fibroblasts is dose-dependent and it associates with increased intracellular zinc concentrations and activated stress response pathways including p53 and stress kinase p38. Higher zinc pyrithione concentrations (500nM and above) stimulate oxidative stress and moderate DNA damage which occur in the presence of activated p38 kinase.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:35:59 GMT 2023
Edited
by admin
on Fri Dec 15 15:35:59 GMT 2023
Record UNII
OBT0841H0M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZINC 2-PYRIDINETHIOL
Systematic Name English
PYRITHIONE ZINC [HSDB]
Common Name English
BIS(2-PYRIDYLTHIO)ZINC
Systematic Name English
2(1H)-PYRIDINETHIONE, ZINC SALT (2:1)
Common Name English
Code System Code Type Description
CAS
13327-60-1
Created by admin on Fri Dec 15 15:35:59 GMT 2023 , Edited by admin on Fri Dec 15 15:35:59 GMT 2023
PRIMARY
PUBCHEM
19966379
Created by admin on Fri Dec 15 15:35:59 GMT 2023 , Edited by admin on Fri Dec 15 15:35:59 GMT 2023
PRIMARY
FDA UNII
OBT0841H0M
Created by admin on Fri Dec 15 15:35:59 GMT 2023 , Edited by admin on Fri Dec 15 15:35:59 GMT 2023
PRIMARY
EPA CompTox
DTXSID20158037
Created by admin on Fri Dec 15 15:35:59 GMT 2023 , Edited by admin on Fri Dec 15 15:35:59 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE