5-FLUORO-8-HYDROXY-2-(DIPROPYLAMINO)TETRALIN HYDROCHLORIDE, (R)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H24FNO.ClH
Molecular Weight	301.827
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 5-FLUORO-8-HYDROXY-2-(DIPROPYLAMINO)TETRALIN HYDROCHLORIDE, (R)-

Structure Search

SMILES

Cl.CCCN(CCC)[C@@H]1CCC2=C(F)C=CC(O)=C2C1

InChI

InChIKey=FKUVCCNCUAFKAH-UTONKHPSSA-N

InChI=1S/C16H24FNO.ClH/c1-3-9-18(10-4-2)12-5-6-13-14(11-12)16(19)8-7-15(13)17;/h7-8,12,19H,3-6,9-11H2,1-2H3;1H/t12-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C16H24FNO
Molecular Weight	265.3663
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19837141

R(+)-UH-301 is a potent and selective 5-HT1A serotonin receptor agonist and works as an antinociceptive agent. In the experiments on rats were shown, that R(+)-UH-301 significantly decrease formalin-induced flinching.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
5-hydroxytryptamine receptor 1A 54 Target ID: P08908 Gene ID: 3350.0 Gene Symbol: HTR1A Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/19837141	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Molecular modelling of UH-301 and 5-HT(1a) receptor interactions.	1996 Feb	9005436
The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats.	2010 Jan 20	19837141

Sample Use Guides

In Vivo Use Guide

in rats: 0.1-3 microg/paw

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:31:49 GMT 2023` Edited by `admin` on `Sat Dec 16 10:31:49 GMT 2023`
Record UNII	O8ROD11G06
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

5-FLUORO-8-HYDROXY-2-(DIPROPYLAMINO)TETRALIN HYDROCHLORIDE, (R)-

Systematic Name

English

1-NAPHTHALENOL, 7-(DIPROPYLAMINO)-4-FLUORO-5,6,7,8-TETRAHYDRO-, HYDROCHLORIDE (1:1), (7R)-

Systematic Name

English

(R)-5-FLUORO-8-HYDROXY-2-(DIPROPYLAMINO)TETRALIN HYDROCHLORIDE

Systematic Name

English

(R)-(+)-5-FLUORO-8-HYDROXY-2-(DIPROPYLAMINO)TETRALIN HYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

O8ROD11G06

Created by admin on Sat Dec 16 10:31:49 GMT 2023 , Edited by admin on Sat Dec 16 10:31:49 GMT 2023

PRIMARY

PUBCHEM

11957726

Created by admin on Sat Dec 16 10:31:49 GMT 2023 , Edited by admin on Sat Dec 16 10:31:49 GMT 2023

PRIMARY

CAS

127126-20-9

Created by admin on Sat Dec 16 10:31:49 GMT 2023 , Edited by admin on Sat Dec 16 10:31:49 GMT 2023

PRIMARY

Related Record Type Details


					44B1597K8X

UH-301 FREE BASE, (R)-

ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/19837141

Approval Year

Targets

Conditions

PubMed

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19837141