PROCAINE MERETHOXYLLINE

US Previously Marketed

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H20HgNO6.C13H20N2O2.HO
Molecular Weight	764.23
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[OH-].CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.COCCOC(C[Hg+])CNC(=O)C2=C(OCC(O)=O)C=CC=C2

InChI

InChIKey=XRCLWOYOVQUZLE-UHFFFAOYSA-M

InChI=1S/C15H20NO6.C13H20N2O2.Hg.H2O/c1-11(21-8-7-20-2)9-16-15(19)12-5-3-4-6-13(12)22-10-14(17)18;1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;;/h3-6,11H,1,7-10H2,2H3,(H,16,19)(H,17,18);5-8H,3-4,9-10,14H2,1-2H3;;1H2/q;;+1;/p-1

HIDE SMILES / InChI

Molecular Formula	C15H20HgNO6
Molecular Weight	510.91
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	C13H20N2O2
Molecular Weight	236.3101
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://books.google.ru/books?id=07g30rxCA0EC&printsec=frontcover&hl=ru#v=onepage&q&f=false

Merethoxylline is a mercurial diuretic. As an equimolar mixture of merethoxylline procaine and theophylline in the molecular proportion 1:1.4 (DICURIN PROCAINE, Lilly) has been used in the treatment of oedema and ascites. The procaine component helps in reducing the discomfort of local irritation caused by mercurial compound when injected into tissues.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
renal sodium ion absorption 3 Target ID: GO:0070294 Sources: https://books.google.ru/books?id=07g30rxCA0EC&printsec=frontcover&hl=ru#v=onepage&q&f=false	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Oedema 7 Sources: Kar, A. (2005) Medicinal Chemistry, page 375, retrieved from: https://books.google.ru/books?id=07g30rxCA0EC	Primary		Approved 8429	DICURIN PROCAINE Approved Use DICURIN PROCAINE has been used in the treatment of oedema and ascites. Launch Date 1981
Ascites 2 Sources: Kar, A. (2005) Medicinal Chemistry, page 375, retrieved from: https://books.google.ru/books?id=07g30rxCA0EC	Primary		Approved 8429	DICURIN PROCAINE Approved Use DICURIN PROCAINE has been used in the treatment of oedema and ascites. Launch Date 1981

Sourcing

Vendor/Aggregator	ID	URL
ChemIDplus	61218471	https://chem.nlm.nih.gov/chemidplus/id/0061218471
PubChem	91667974	https://pubchem.ncbi.nlm.nih.gov/compound/91667974
Wikidata	Q27252166

PubMed

Title	Date	PubMed
Study of the mercurial diuretic, dicurin procaine (merethoxylline procaine) by subcutaneous injection.	1953 Feb	13016553
NEW AND nonofficial remedies: merethoxylline.	1954 Aug 21	13183776
NEW AND nonofficial remedies: merethoxylline procaine.	1954 Aug 21	13183775

Patents

Sample Use Guides

In Vivo Use Guide

Ususal i.m., s.c. daily 0.5 to 5 ml (containing 100 mg procaine merethoxylline and 50 mg of theophylline per ml)

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:05:12 GMT 2023` Edited by `admin` on `Fri Dec 15 15:05:12 GMT 2023`
Record UNII	O77D636VYN
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PROCAINE MERETHOXYLLINE

Common Name

English

PROCAINE MERETHOXYLLINE [ORANGE BOOK]

Common Name

English

MERETHOXYLLINE PROCAINE

Common Name

English

PROCAINE MERETHOXYLLINE COMPONENT OF DICURIN PROCAINE

Common Name

English

MERETHOXYLINE PROCAINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C245