Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H22BrNO |
| Molecular Weight | 420.342 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCN1C=C(C(=O)C2=CC=CC3=C2C(Br)=CC=C3)C4=C1C=CC=C4
InChI
InChIKey=QXZYVJRMQVOOEQ-UHFFFAOYSA-N
InChI=1S/C24H22BrNO/c1-2-3-6-15-26-16-20(18-11-4-5-14-22(18)26)24(27)19-12-7-9-17-10-8-13-21(25)23(17)19/h4-5,7-14,16H,2-3,6,15H2,1H3
| Molecular Formula | C24H22BrNO |
| Molecular Weight | 420.342 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:17:33 GMT 2023
by
admin
on
Sat Dec 16 11:17:33 GMT 2023
|
| Record UNII |
O4Q3AIP6BJ
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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Systematic Name | English | ||
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Systematic Name | English |
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WIKIPEDIA |
Designer-drugs-JWH-424
Created by
admin on Sat Dec 16 11:17:33 GMT 2023 , Edited by admin on Sat Dec 16 11:17:33 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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57458937
Created by
admin on Sat Dec 16 11:17:33 GMT 2023 , Edited by admin on Sat Dec 16 11:17:33 GMT 2023
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PRIMARY | |||
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1366068-04-3
Created by
admin on Sat Dec 16 11:17:33 GMT 2023 , Edited by admin on Sat Dec 16 11:17:33 GMT 2023
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PRIMARY | |||
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O4Q3AIP6BJ
Created by
admin on Sat Dec 16 11:17:33 GMT 2023 , Edited by admin on Sat Dec 16 11:17:33 GMT 2023
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PRIMARY | |||
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DTXSID50159855
Created by
admin on Sat Dec 16 11:17:33 GMT 2023 , Edited by admin on Sat Dec 16 11:17:33 GMT 2023
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PRIMARY | |||
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JWH-424
Created by
admin on Sat Dec 16 11:17:33 GMT 2023 , Edited by admin on Sat Dec 16 11:17:33 GMT 2023
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PRIMARY | JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).1 This cannabimimetic compound has frequently been found in herbal blends. 2,3,4 JWH 424 is an 8-bromonaphthyl derivative of JWH 018 which shows a reduced selectivity for CB1 over CB2 (Ki = 20.9 and 5.4 nM, respectively). The properties of this compound in vivo are not known. This product is intended for forensic and research applications. | ||
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JWH-424
Created by
admin on Sat Dec 16 11:17:33 GMT 2023 , Edited by admin on Sat Dec 16 11:17:33 GMT 2023
|
PRIMARY | JWH-424 is a drug from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, but with moderate selectivity for CB2, having a Ki of 5.44nM at CB2 vs 20.9nM at CB1. The heavier 8-iodo analogue is even more CB2 selective, with its 2-methyl derivative having 40x selectivity for CB2. However the 1-propyl homologues in this series showed much lower affinity at both receptors, reflecting a generally reduced affinity for the 8-substituted naphthoylindoles overall. |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
