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Details

Stereochemistry ACHIRAL
Molecular Formula Ca.2F
Molecular Weight 78.075
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CALCIUM FLUORIDE

SMILES

[F-].[F-].[Ca++]

InChI

InChIKey=WUKWITHWXAAZEY-UHFFFAOYSA-L
InChI=1S/Ca.2FH/h;2*1H/q+2;;/p-2

HIDE SMILES / InChI

Molecular Formula FH
Molecular Weight 20.00634
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf

Olaflur (amine fluoride 297, trade name elmex gel) is a fluoride-containing substance that is an ingredient of toothpastes and solutions for the prevention of dental caries. Especially in combination with dectaflur, it is also used in the form of gels for the treatment of early stages of caries, sensitive teeth, and by dentists for the refluoridation of damaged tooth enamel. Olaflur is a salt consisting of an alkyl ammonium cation and fluoride as the counterion. With a long lipophilic hydrocarbon chain, the cation has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the enamel. The top layers of the enamel's primary mineral, hydroxylapatite, are converted into the more robust fluorapatite. The fluoridation reaches only a depth of a few nanometres, which has raised doubts whether the mechanism really relies on the formation of fluorapatite.

CNS Activity

Originator

Sources: Helvetica Odontologica Acta (1962), 6, (1), 15-20.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
elmex

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Allergic contact cheilitis caused by olaflur in toothpaste.
2017-01
Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability.
2015-06
Oleylamine as a beneficial agent for the synthesis of CoFe₂O₄ nanoparticles with potential biomedical uses.
2014-05-07
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013-01
Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes.
2007-10
Epidemiology of 377 patients with chemical burns in Guangdong province.
2004-09
An improved method for emergent decontamination of ocular and dermal hydrofluoric acid splashes.
2004-08
Patents

Patents

Sample Use Guides

toxicity in mice: LD50 = 888 mg/kg
Route of Administration: Intraperitoneal
Cytotoxicity study: it was explored the cytotoxicity of the coating agent, Oleylamine in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h, and 24 h were employed for the study. Oleylamine, is highly toxic, leading to almost 100% cell death.
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:59:38 GMT 2025
Edited
by admin
on Mon Mar 31 17:59:38 GMT 2025
Record UNII
O3B55K4YKI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CALCIUM FLUORIDE
HSDB   INCI   MART.   MI   WHO-DD  
INCI  
Official Name English
CALCAREA FLUORICA
HPUS  
Preferred Name English
CALCIUM FLUORIDE [HSDB]
Common Name English
CALCIUM FLUORIDE [MI]
Common Name English
FLUORITUM
CHP  
Common Name English
CALCIUM FLUORITE
Systematic Name English
FLUORITE
Systematic Name English
ZISHIYIN
Common Name English
Calcium fluoride [WHO-DD]
Common Name English
PURPLE STONE RADIANCE
Common Name English
CALCIUM FLUORIDE [MART.]
Common Name English
AMETHYSTUM
Common Name English
ZI SHI YING
Common Name English
FLUORITUM [CHP]
Common Name English
CALCII FLUORIDUM
Common Name English
FLUORSPAR
Common Name English
CALCAREA FLUORICA [HPUS]
Common Name English
Code System Code Type Description
CAS
7789-75-5
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
EPA CompTox
DTXSID4050487
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
EVMPD
SUB96138
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
ALTERNATIVE
MESH
D002124
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
PUBCHEM
24617
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
HSDB
995
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
EVMPD
SUB130901
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
ALTERNATIVE
FDA UNII
O3B55K4YKI
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
WIKIPEDIA
CALCIUM FLUORIDE
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
SMS_ID
100000076584
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
MERCK INDEX
m2939
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY Merck Index
CHEBI
46713
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
RXCUI
1905
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY RxNorm
ECHA (EC/EINECS)
232-188-7
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
DAILYMED
O3B55K4YKI
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
EVMPD
SUB13174MIG
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
EVMPD
SUB34726
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
CHEBI
35437
Created by admin on Mon Mar 31 17:59:38 GMT 2025 , Edited by admin on Mon Mar 31 17:59:38 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY