Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C9H12BNO4.ClH |
| Molecular Weight | 245.468 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.N[C@@H](CC1=CC=C(C=C1)B(O)O)C(O)=O
InChI
InChIKey=ITAYDCRFNXQNBL-QRPNPIFTSA-N
InChI=1S/C9H12BNO4.ClH/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15;/h1-4,8,14-15H,5,11H2,(H,12,13);1H/t8-;/m0./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C9H12BNO4 |
| Molecular Weight | 209.007 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax. | 2010-12-02 |
|
| Aryl boronic acid inhibition of synthetic melanin polymerization. | 2010-08-01 |
|
| Early effect of boron neutron capture therapy mediated by boronophenylalanine (BPA-BNCT) on mast cells in premalignant tissue and tumors of the hamster cheek pouch. | 2010-05 |
|
| Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma. | 2009-12-11 |
|
| Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors. | 2009-12 |
|
| Boron neutron capture therapy of EGFR or EGFRvIII positive gliomas using either boronated monoclonal antibodies or epidermal growth factor as molecular targeting agents. | 2009-07 |
|
| Boron neutron capture therapy at the crossroads: challenges and opportunities. | 2009-07 |
|
| Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT. | 2009-07 |
|
| In vitro neutron irradiation of glioma and endothelial cultured cells. | 2009-07 |
|
| Calculations of dose distributions in the lungs of a rat model irradiated in the thermal column of the TRIGA reactor in Pavia. | 2009-07 |
|
| Selective uptake of p-boronophenylalanine by osteosarcoma cells for boron neutron capture therapy. | 2009-07 |
|
| Feasibility of boron neutron capture therapy for malignant spinal tumors. | 2009-07 |
|
| Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: an experimental study that supports a potential new application of BNCT. | 2009-07 |
|
| Boronophenylalanine uptake in C6 glioma model is dramatically increased by L-DOPA preloading. | 2009-07 |
|
| Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life. | 2009-05-13 |
|
| Insight into the mechanisms underlying tumor response to boron neutron capture therapy in the hamster cheek pouch oral cancer model. | 2009-05 |
|
| Planned fractionated boron neutron capture therapy using epithermal neutrons for a patient with recurrent squamous cell carcinoma in the temporal bone: a case report. | 2009-03 |
|
| Boron neutron capture therapy for newly diagnosed glioblastoma. | 2009-01 |
|
| An international dosimetry exchange for BNCT part II: computational dosimetry normalizations. | 2008-12 |
|
| Comments to article: Henriksson R et al., Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA) Radiother Oncol (2008). | 2008-08 |
|
| Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA). | 2008-08 |
|
| Application of drug delivery system to boron neutron capture therapy for cancer. | 2008-04 |
|
| Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: towards a novel therapy for liver metastases. | 2007-10 |
|
| Therapeutic effect of boron neutron capture therapy (BNCT) on field cancerized tissue: inhibition of DNA synthesis and lag in the development of second primary tumors in precancerous tissue around treated tumors in DMBA-induced carcinogenesis in the hamster cheek pouch oral cancer model. | 2007-03 |
|
| Molecular targeting and treatment of an epidermal growth factor receptor-positive glioma using boronated cetuximab. | 2007-02-15 |
|
| Early effects of boron neutron capture therapy on rat glioma models. | 2007 |
|
| Impact of intra-arterial administration of boron compounds on dose-volume histograms in boron neutron capture therapy for recurrent head-and-neck tumors. | 2006-12-01 |
|
| Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): chemical analyses in the hamster cheek pouch oral cancer model. | 2006-10 |
|
| Therapeutic success of boron neutron capture therapy (BNCT) mediated by a chemically non-selective boron agent in an experimental model of oral cancer: a new paradigm in BNCT radiobiology. | 2006-08 |
|
| Pharmacokinetic study of BSH and BPA in simultaneous use for BNCT. | 2006-07 |
|
| Molecular targeting and treatment of EGFRvIII-positive gliomas using boronated monoclonal antibody L8A4. | 2006-06-15 |
|
| Boron containing macromolecules and nanovehicles as delivery agents for neutron capture therapy. | 2006-03 |
|
| Histopathological changes of testes and eyes by neutron irradiation with boron compounds in mice. | 2006-03 |
|
| Capillary electrophoresis-electrospray mass spectrometry and HR-ICP-MS for the detection and quantification of 10B-boronophenylalanine (10B-BPA) used in boron neutron capture therapy. | 2006-02 |
|
| Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages. | 2005-12 |
|
| Noninvasive quantitative in vivo mapping and metabolism of boronophenylalanine (BPA) by nuclear magnetic resonance (NMR) spectroscopy and imaging. | 2005-11 |
|
| Boron neutron capture therapy of cancer: current status and future prospects. | 2005-06-01 |
|
| Optimized 1H MRS and MRSI methods for the in vivo detection of boronophenylalanine. | 2005-05 |
|
| Boron neutron capture therapy for glioblastoma multiforme. | 2005-04 |
|
| Effectiveness of BNCT for recurrent head and neck malignancies. | 2004-11 |
|
| Boronated epidermal growth factor as a delivery agent for neutron capture therapy of EGF receptor positive gliomas. | 2004-11 |
|
| Radiobiology of BNCT mediated by GB-10 and GB-10+BPA in experimental oral cancer. | 2004-11 |
|
| The effect of dexamethasone on the uptake of p-boronophenylalanine in the rat brain and intracranial 9L gliosarcoma. | 2004-11 |
|
| Neutron capture therapy of epidermal growth factor (+) gliomas using boronated cetuximab (IMC-C225) as a delivery agent. | 2004-11 |
|
| MicroPET-based pharmacokinetic analysis of the radiolabeled boron compound [18F]FBPA-F in rats with F98 glioma. | 2004-11 |
|
| Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors. | 2004-09-01 |
|
| Synchrotron radiation-based experimental determination of the optimal energy for cell radiotoxicity enhancement following photoelectric effect on stable iodinated compounds. | 2004-08-02 |
|
| Accumulation of boron in human malignant glioma cells in vitro is cell type dependent. | 2004-07 |
|
| Delivery of (10)boron to oral squamous cell carcinoma using boronophenylalanine and borocaptate sodium for boron neutron capture therapy. | 2004-05 |
|
| A microdosimetric approach to the thermal neutron fluence prescription for clinical BNCT. | 2004 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:44:46 GMT 2025
by
admin
on
Mon Mar 31 20:44:46 GMT 2025
|
| Record UNII |
O37300B3AP
|
| Record Status |
Validated (UNII)
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| Record Version |
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O37300B3AP
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71423166
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DTXSID30227243
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76410-59-8
Created by
admin on Mon Mar 31 20:44:46 GMT 2025 , Edited by admin on Mon Mar 31 20:44:46 GMT 2025
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