Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H27NO9 |
| Molecular Weight | 461.4618 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12C=C[C@H](O)[C@@H]3OC4=C5C(C[C@H]1N(C)CC[C@@]235)=CC=C4O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O
InChI
InChIKey=WAEXKFONHRHFBZ-ZXDZBKESSA-N
InChI=1S/C23H27NO9/c1-24-7-6-23-10-3-4-12(25)20(23)32-18-13(5-2-9(14(18)23)8-11(10)24)31-22-17(28)15(26)16(27)19(33-22)21(29)30/h2-5,10-12,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,12-,15-,16-,17+,19-,20-,22+,23-/m0/s1
| Molecular Formula | C23H27NO9 |
| Molecular Weight | 461.4618 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Lack of effect of ondansetron on the pharmacokinetics and analgesic effects of morphine and metabolites after single-dose morphine administration in healthy volunteers. | 2001 Apr |
|
| Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms. | 2001 Nov |
|
| Ethnicity influences morphine pharmacokinetics and pharmacodynamics. | 2001 Oct |
|
| Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns. | 2002 |
|
| Verapamil decreases glucuronidase activity in the gut. | 2002 Apr 15 |
|
| Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability. | 2002 Dec |
|
| Diclofenac does not interact with codeine metabolism in vivo: a study in healthy volunteers. | 2002 Feb 27 |
|
| Pain, sedation and morphine metabolism in cancer patients during long-term treatment with sustained-release morphine. | 2002 Mar |
|
| The study of codeine-gluthetimide pharmacokinetic interaction in rats. | 2003 Aug 8 |
|
| The oral-to-intravenous equianalgesic ratio of morphine based on plasma concentrations of morphine and metabolites in advanced cancer patients receiving chronic morphine treatment. | 2003 Dec |
|
| [Development of opioid tolerance -- molecular mechanisms and clinical consequences]. | 2003 Jan |
|
| Influences on serum concentrations of morphine, M6G and M3G during routine clinical drug monitoring: a prospective survey in 300 adult cancer patients. | 2003 Jul |
|
| The pharmacokinetics of the interstitial space in humans. | 2003 Jul 30 |
|
| High levels of morphine-6-glucuronide in street heroin addicts. | 2003 Nov |
|
| The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. | 2003 Oct |
|
| Determination of morphine and morphine glucuronides in human plasma by 96-well plate solid-phase extraction and liquid chromatography-electrospray ionization mass spectrometry. | 2003 Oct 25 |
|
| Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children. | 2004 Feb |
|
| Comparison of the antinociceptive effect of morphine, methadone, buprenorphine and codeine in two substrains of Sprague-Dawley rats. | 2004 May 10 |
|
| Determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in monkey and dog plasma by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. | 2004 May 28 |
|
| Simultaneous measurement and integrated analysis of analgesia and respiration after an intravenous morphine infusion. | 2004 Nov |
|
| Validated assay for the determination of markers of illicit heroin in urine samples for the control of patients in a heroin prescription program. | 2004 Nov 5 |
|
| Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents. | 2005 Apr |
|
| The contribution of fetal metabolism to the disposition of morphine. | 2005 Jan |
|
| Development and validation of a radioreceptor assay for the determination of morphine and its active metabolites in serum. | 2005 Oct 4 |
|
| Optimizing recombinant antibody function in SPR immunosensing. The influence of antibody structural format and chip surface chemistry on assay sensitivity. | 2006 Aug 15 |
|
| Direct nose-to-brain transfer of morphine after nasal administration to rats. | 2006 Mar |
|
| An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites. | 2006 May |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Jul 05 22:54:28 UTC 2023
by
admin
on
Wed Jul 05 22:54:28 UTC 2023
|
| Record UNII |
O27Z9CH39A
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
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Common Name | English |
| Code System | Code | Type | Description | ||
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MORPHINE-3-GLUCURONIDE
Created by
admin on Wed Jul 05 22:54:28 UTC 2023 , Edited by admin on Wed Jul 05 22:54:28 UTC 2023
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DTXSID80174157
Created by
admin on Wed Jul 05 22:54:28 UTC 2023 , Edited by admin on Wed Jul 05 22:54:28 UTC 2023
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O27Z9CH39A
Created by
admin on Wed Jul 05 22:54:28 UTC 2023 , Edited by admin on Wed Jul 05 22:54:28 UTC 2023
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20290-09-9
Created by
admin on Wed Jul 05 22:54:28 UTC 2023 , Edited by admin on Wed Jul 05 22:54:28 UTC 2023
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5484731
Created by
admin on Wed Jul 05 22:54:28 UTC 2023 , Edited by admin on Wed Jul 05 22:54:28 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> METABOLITE |
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PARENT -> METABOLITE INACTIVE |
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
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