Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H3Cl2F |
| Molecular Weight | 116.95 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(F)(Cl)Cl
InChI
InChIKey=FRCHKSNAZZFGCA-UHFFFAOYSA-N
InChI=1S/C2H3Cl2F/c1-2(3,4)5/h1H3
| Molecular Formula | C2H3Cl2F |
| Molecular Weight | 116.95 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
1,1-dichloro-1-fluoroethane (Hydrochlorofluorocarbon-141b, or HCFC141b), has been developed as a replacement for fully halogenated chlorofluorocarbons because its residence time in the atmosphere is shorter, and its ozone depleting potential is lower than that of presently used chlorofluorocarbons. HCFC-141b is used in the production of rigid polyurethane and polyisocyanurate or phenolic insulation foams for residential and commercial buildings. It may also be used as a solvent in electronic and other precision cleaning applications. HCFC-141b is of low inhalation toxicity. Uptake and elimination are rapid, and most of the absorbed dose is excreted unchanged in the exhaled air.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Occupational asthma in Korea. | 2010-12 |
|
| Halocarbon emissions from the United States and Mexico and their global warming potential. | 2009-02-15 |
|
| Uncontrolled occupational exposure to 1,1-dichloro-1-Fluoroethane (HCFC-141b) is associated with acute pulmonary toxicity. | 2009-01 |
|
| European emissions of HFC-365mfc, a chlorine-free substitute for the foam blowing agents HCFC-141b and CFC-11. | 2007-02-15 |
|
| Airborne methylene diphenyl diisocyanate (MDI) concentrations associated with the application of polyurethane spray foam in residential construction. | 2007-02 |
|
| Micronuclei induction by 13 week-inhalation of 1,1-dichloro-1-fluoroethane in Sprague-Dawley rats. | 2004-01-15 |
|
| Source reduction for prevention of methylene chloride hazards: cases from four industrial sectors. | 2003-07-21 |
|
| High-pressure hand injection injuries caused by dry cleaning solvents: case reports, review of the literature, and treatment guidelines. | 2003-01 |
|
| Bioactivation and toxicity in vitro of HCFC-123 and HCFC-141b: role of cytochrome P450. | 2001-10-15 |
|
| Neoantigen formation and clastogenic action of HCFC-123 and perchloroethylene in human MCL-5 cells. | 2001-10-15 |
|
| Selective inactivation of rat and bovine olfactory cytochrome P450 by three haloethanes. | 2001-10-15 |
|
| Bioactivation to free radicals and cytotoxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b). | 2001-02 |
|
| Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450. | 1996-04 |
|
| Evaluation of the genotoxicity potential and chronic inhalation toxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b). | 1995-06 |
|
| Gas-uptake pharmacokinetics and biotransformation of 1,1-dichloro-1-fluoroethane (HCFC-141b). | 1993-07-01 |
Patents
Sample Use Guides
Human subjects were exposed by inhalation to 250, 500, and 1000 ppm 1,1-dichloro-1-fluoroethane (HCFC-141b) for 4 hr
Route of Administration:
Respiratory
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:24:34 GMT 2025
by
admin
on
Mon Mar 31 19:24:34 GMT 2025
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| Record UNII |
O1A3ASY5PW
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| Record Status |
Validated (UNII)
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CFR |
21 CFR 189.191
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1,1-Dichloro-1-fluoroethane
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O1A3ASY5PW
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