1,1-DICHLORO-1-FLUOROETHANE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H3Cl2F
Molecular Weight	116.95
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 1,1-DICHLORO-1-FLUOROETHANE

Structure Search

SMILES

CC(F)(Cl)Cl

InChI

InChIKey=FRCHKSNAZZFGCA-UHFFFAOYSA-N

InChI=1S/C2H3Cl2F/c1-2(3,4)5/h1H3

HIDE SMILES / InChI

Molecular Formula	C2H3Cl2F
Molecular Weight	116.95
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/books/NBK207608/ | https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+6757 | http://www.inchem.org/documents/sids/sids/1717006.pdf

1,1-dichloro-1-fluoroethane (Hydrochlorofluorocarbon-141b, or HCFC141b), has been developed as a replacement for fully halogenated chlorofluorocarbons because its residence time in the atmosphere is shorter, and its ozone depleting potential is lower than that of presently used chlorofluorocarbons. HCFC-141b is used in the production of rigid polyurethane and polyisocyanurate or phenolic insulation foams for residential and commercial buildings. It may also be used as a solvent in electronic and other precision cleaning applications. HCFC-141b is of low inhalation toxicity. Uptake and elimination are rapid, and most of the absorbed dose is excreted unchanged in the exhaled air.

Approval Year

PubMed

Title	Date	PubMed
Gas-uptake pharmacokinetics and biotransformation of 1,1-dichloro-1-fluoroethane (HCFC-141b).	1993 Jul-Aug	8104122
Evaluation of the genotoxicity potential and chronic inhalation toxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b).	1995 Jun	7797176
Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450.	1996 Apr	9173683
Bioactivation and toxicity in vitro of HCFC-123 and HCFC-141b: role of cytochrome P450.	2001 Oct 15	11684366
Selective inactivation of rat and bovine olfactory cytochrome P450 by three haloethanes.	2001 Oct 15	11684360
High-pressure hand injection injuries caused by dry cleaning solvents: case reports, review of the literature, and treatment guidelines.	2003 Jan	12496578
European emissions of HFC-365mfc, a chlorine-free substitute for the foam blowing agents HCFC-141b and CFC-11.	2007 Feb 15	17593712
Uncontrolled occupational exposure to 1,1-dichloro-1-Fluoroethane (HCFC-141b) is associated with acute pulmonary toxicity.	2009 Jan	18689598

Patents

Sample Use Guides

In Vivo Use Guide

Human subjects were exposed by inhalation to 250, 500, and 1000 ppm 1,1-dichloro-1-fluoroethane (HCFC-141b) for 4 hr

Route of Administration: Respiratory

In Vitro Use Guide

In vitro, chromosome aberration assays were negative with human lymphocytes at vapor concentrations of 1.25% to 35% v/v; incubation times ranged from 3 to 24 h

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:53:52 GMT 2023` Edited by `admin` on `Fri Dec 15 18:53:52 GMT 2023`
Record UNII	O1A3ASY5PW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1,1-DICHLORO-1-FLUOROETHANE

Systematic Name

English

1-FLUORO-1,1-DICHLOROETHANE

Systematic Name

English

HCFC-141B

Common Name

English

ETHANE, 1,1-DICHLORO-1-FLUORO-

Systematic Name

English

1,1-DICHLORO-1-FLUOROETHANE [HSDB]

Common Name

English

RC-14

Common Name

English

DICHLORO-1-FLUOROETHANE, 1,1-

Systematic Name

English

R-141B

Common Name

English

REFRIGERANT-141B

Common Name

English

CFC-141B

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 189.191