GSK-3965193

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H25ClN2O5
Molecular Weight	432.897
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COCCCOC1=C(Cl)N=C2C(=C1)[C@H]3CCC(C)(C)[C@H]3N4C=C(C(O)=O)C(=O)C=C24

InChI

InChIKey=JFVCUINASNRMTO-BLVKFPJESA-N

InChI=1S/C22H25ClN2O5/c1-22(2)6-5-12-13-9-17(30-8-4-7-29-3)20(23)24-18(13)15-10-16(26)14(21(27)28)11-25(15)19(12)22/h9-12,19H,4-8H2,1-3H3,(H,27,28)/t12-,19+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H25ClN2O5
Molecular Weight	432.897
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Wed Apr 02 19:16:51 GMT 2025` Edited by `admin` on `Wed Apr 02 19:16:51 GMT 2025`
Record UNII	NZZ7UWE8JN
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GSK3965193

Preferred Name

English

GSK-3965193

Code

English

10-chloro-9-(3-methoxypropoxy)-3,3-dimethyl-15-oxo-1,11-diazatetracyclo[11.4.0.02,6.07,12]heptadeca-7,9,11,13,16-pentaene-16-carboxylic acid, (2S,6R)-

Systematic Name

English

GSK3965193B FREE ACID

Code

English

(4bR,7aS)-2-Chloro-4b,5,6,7,7a,11-hexahydro-3-(3-methoxypropoxy)-7,7-dimethyl-11-oxocyclopenta[f]pyrido[1,2-h][1,7]naphthyridine-10-carboxylic acid

Systematic Name

English

Cyclopenta[f]pyrido[1,2-h][1,7]naphthyridine-10-carboxylic acid, 2-chloro-4b,5,6,7,7a,11-hexahydro-3-(3-methoxypropoxy)-7,7-dimethyl-11-oxo-, (4bR,7aS)-

Systematic Name

English

(2S,6R)-10-chloro-9-(3-methoxypropoxy)-3,3-dimethyl-15-oxo-1,11-diazatetracyclo[11.4.0.02,6.07,12]heptadeca-7,9,11,13,16-pentaene-16-carboxylic acid

Systematic Name

English

Code System Code Type Description

PUBCHEM

138523931

Created by admin on Wed Apr 02 19:16:51 GMT 2025 , Edited by admin on Wed Apr 02 19:16:51 GMT 2025

PRIMARY

CAS

2305766-58-7

Created by admin on Wed Apr 02 19:16:51 GMT 2025 , Edited by admin on Wed Apr 02 19:16:51 GMT 2025

PRIMARY

SMS_ID

300000054252

Created by admin on Wed Apr 02 19:16:51 GMT 2025 , Edited by admin on Wed Apr 02 19:16:51 GMT 2025

PRIMARY

FDA UNII

NZZ7UWE8JN

Created by admin on Wed Apr 02 19:16:51 GMT 2025 , Edited by admin on Wed Apr 02 19:16:51 GMT 2025

PRIMARY

Related Record Type Details


					77H9EM77P7

HEPATITIS B VIRUS

TARGET ORGANISM->INHIBITOR

Amount:


					CVK7APF89T

Terminal nucleotidyltransferase 4B

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					NZZ7UWE8JN

GSK-3965193

ACTIVE MOIETY

Comments:

Acts as an RNA destabilizer by inhibiting PAPD5/7 to degrade HBV RNA.

Amount: