Birinkibart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:01:44 GMT 2025` Edited by `admin` on `Wed Apr 02 13:01:44 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	NXQ9Y7M8UC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-gamma4 heavy chain Homo sapiens (1-450) [VH (Homo sapiens IGHV1-24*01 (94.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10(CH1 (124-221), hinge 1-12 S10>P (231) (222-233),

Preferred Name

English

Birinkibart

Official Name

English

birinkibart [INN]

Common Name

English

Immunoglobulin G4-kappa, anti-[Homo sapiens CSF2RB (colony stimulating factor 2 (CSF2) receptor subunit beta, granulocytemacrophage colony stimulating factor (GM-CSF) receptor subunit beta, beta common cytokine receptor, IL3RB, IL5RB, CD131)], Homo sapie

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C211791

Created by admin on Wed Apr 02 13:01:44 GMT 2025 , Edited by admin on Wed Apr 02 13:01:44 GMT 2025

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FDA UNII

NXQ9Y7M8UC

Created by admin on Wed Apr 02 13:01:44 GMT 2025 , Edited by admin on Wed Apr 02 13:01:44 GMT 2025

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CAS

2894136-82-2

Created by admin on Wed Apr 02 13:01:44 GMT 2025 , Edited by admin on Wed Apr 02 13:01:44 GMT 2025

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SMS_ID

300000056820

Created by admin on Wed Apr 02 13:01:44 GMT 2025 , Edited by admin on Wed Apr 02 13:01:44 GMT 2025

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INN

13121

Created by admin on Wed Apr 02 13:01:44 GMT 2025 , Edited by admin on Wed Apr 02 13:01:44 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_137	4_214
2_150	2_206
2_264	2_324
1_137	3_214
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_150	1_206
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					NXQ9Y7M8UC

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q	Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL