Cibotercept

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 19:51:27 GMT 2023` Edited by `admin` on `Sat Dec 16 19:51:27 GMT 2023`
Protein Type	FUSION PROTEINS
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	NV26E66EB5
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Cibotercept

Official Name

English

2-116-Activin receptor type IIB [12-leucine,28-valine,35-lysine,51-serine,52-leucine,54-isoleucine,70-aspartic acid,71-threonine,76-lysine,90-methionine] (human) fusion protein with peptide linker (GGG) fusion protein with immunoglobulin G1 (human γ1-ch

Common Name

English

cibotercept [INN]

Common Name

English

Code System Code Type Description

INN

12740

Created by admin on Sat Dec 16 19:51:27 GMT 2023 , Edited by admin on Sat Dec 16 19:51:27 GMT 2023

PRIMARY

FDA UNII

NV26E66EB5

Created by admin on Sat Dec 16 19:51:27 GMT 2023 , Edited by admin on Sat Dec 16 19:51:27 GMT 2023

PRIMARY

CAS

2769700-97-0

Created by admin on Sat Dec 16 19:51:27 GMT 2023 , Edited by admin on Sat Dec 16 19:51:27 GMT 2023

PRIMARY

From	To
1_127	2_127
1_124	2_124
1_265	1_323
2_265	2_323
1_159	1_219
2_159	2_219
1_85	1_90
2_85	2_90
1_71	1_83
2_71	2_83
1_65	1_84
2_65	2_84
1_30	1_58
2_30	2_58
1_10	1_40
2_10	2_40

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_23
N	1_46
N	1_195
N	2_23
N	2_46
N	2_195
O	1_115
O	2_115

Related Record Type Details


					NV26E66EB5

Cibotercept

ACTIVE MOIETY

Comments:

inhibition of SMAD2/3 (pro-proliferative) signaling, while permitting signaling of SMAD1/5/9 (anti-proliferative). This inhibition is expected to rebalance the defective SMAD

Amount: