Cibotercept

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 17:29:33 GMT 2025` Edited by `admin` on `Wed Apr 02 17:29:33 GMT 2025`
Protein Type	FUSION PROTEINS
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	NV26E66EB5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ActRIIB 2.12

Preferred Name

English

Cibotercept

Official Name

English

2-116-Activin receptor type IIB [12-leucine,28-valine,35-lysine,51-serine,52-leucine,54-isoleucine,70-aspartic acid,71-threonine,76-lysine,90-methionine] (human) fusion protein with peptide linker (GGG) fusion protein with immunoglobulin G1 (human ?1-cha

Systematic Name

English

cibotercept [INN]

Common Name

English

Human activin receptor type 2-B (activin receptor type IIB, ACTR-IIB) extracellular domain (ECD) fragment (2-116, 1-115 in the current sequence), engineered variant (S1>del, I11>L, L27>V, Q34>K, 50TI51>SL, L53>I, 69QE70>DT, E75>K, F89>M) fused via the pe

Systematic Name

English

CIBOTERCEPT [USAN]

Common Name

English

Code System Code Type Description

INN

12740

Created by admin on Wed Apr 02 17:29:33 GMT 2025 , Edited by admin on Wed Apr 02 17:29:33 GMT 2025

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FDA UNII

NV26E66EB5

Created by admin on Wed Apr 02 17:29:33 GMT 2025 , Edited by admin on Wed Apr 02 17:29:33 GMT 2025

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NCI_THESAURUS

C203042

Created by admin on Wed Apr 02 17:29:33 GMT 2025 , Edited by admin on Wed Apr 02 17:29:33 GMT 2025

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USAN

MN-199

Created by admin on Wed Apr 02 17:29:33 GMT 2025 , Edited by admin on Wed Apr 02 17:29:33 GMT 2025

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CAS

2769700-97-0

Created by admin on Wed Apr 02 17:29:33 GMT 2025 , Edited by admin on Wed Apr 02 17:29:33 GMT 2025

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SMS_ID

300000047761

Created by admin on Wed Apr 02 17:29:33 GMT 2025 , Edited by admin on Wed Apr 02 17:29:33 GMT 2025

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From	To
1_127	2_127
1_124	2_124
1_265	1_323
2_265	2_323
1_159	1_219
2_159	2_219
1_85	1_90
2_85	2_90
1_71	1_83
2_71	2_83
1_65	1_84
2_65	2_84
1_30	1_58
2_30	2_58
1_10	1_40
2_10	2_40

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_23
N	1_46
N	1_195
N	2_23
N	2_46
N	2_195
O	1_115
O	2_115

Related Record Type Details


					NV26E66EB5

ACTIVE MOIETY

Comments:

inhibition of SMAD2/3 (pro-proliferative) signaling, while permitting signaling of SMAD1/5/9 (anti-proliferative). This inhibition is expected to rebalance the defective SMAD

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_345] [2_345]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL