Suvutresgene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 09:43:17 GMT 2025` Edited by `admin` on `Wed Apr 02 09:43:17 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	peripheral blood leucocytes
Record UNII	NU51FEX15J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Suvutresgene Autoleucel

Official Name

English

Autologous T lymphocytes obtained from peripheral blood lymphocytes by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding an affinity-enhanced cancer testis antigen (NY-ESO-1 c259 ) specific T-cell receptor (TC

Preferred Name

English

suvutresgene autoleucel [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C199017

Created by admin on Wed Apr 02 09:43:17 GMT 2025 , Edited by admin on Wed Apr 02 09:43:17 GMT 2025

PRIMARY

SMS_ID

300000013662

Created by admin on Wed Apr 02 09:43:17 GMT 2025 , Edited by admin on Wed Apr 02 09:43:17 GMT 2025

PRIMARY

INN

12538

Created by admin on Wed Apr 02 09:43:17 GMT 2025 , Edited by admin on Wed Apr 02 09:43:17 GMT 2025

PRIMARY

FDA UNII

NU51FEX15J

Created by admin on Wed Apr 02 09:43:17 GMT 2025 , Edited by admin on Wed Apr 02 09:43:17 GMT 2025

PRIMARY

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					CK9V945ORX

TGF-BETA RECEPTOR TYPE-2

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					NU51FEX15J

Suvutresgene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217
CULTURE	ACTIVATOR	BIOLOGICAL	ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M
TRANSFECTION FOLLOWED BY EXPANSION AND RELEASE FROM MAGNETIC BEADS		BIOLOGICAL	Suvutresgene autoleucel lentiviral vector	BB2IRH667X

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
TRANSGENE					Suvutresgene autoleucel transgene insert	CY0DG265DT
VECTOR EXPRESSED PROTEIN					Suvutresgene autoleucel expressed preprotein	W5AS9HH8DV