ZAMTOCABTAGENE AUTOLEUCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 06:26:15 GMT 2025` Edited by `admin` on `Wed Apr 02 06:26:15 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	t cells
Record UNII	NT3BAN5MDV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AUTOLOGOUS T CELLS OBTAINED FROM PERIPHERAL BLOOD COLLECTED BY LEUKAPHERESIS, TRANSDUCED WITH A NON-REPLICATING LENTIVIRAL VECTOR, PSEUDOTYPED WITH VESICULAR STOMATITIS VIRUS (VSV) GLYCOPROTEIN (G), ENCODING A CODON-OPTIMIZED CHIMERIC ANTIGEN RECEPTOR (C

Preferred Name

English

ZAMTOCABTAGENE AUTOLEUCEL

Official Name

English

zamtocabtagene autoleucel [INN]

Common Name

English

CELLS ARE ACTIVATED IN THE PRESENCE OF A COLLOIDAL POLYMERIC NANOMATRIX COVALENTLY ATTACHED TO ANTI-CD3 AND ANTI-CD28, TRANSDUCED, AND THEN CULTURED IN THE PRESENCE OF IL-7 AND IL-15. THE T CELLS ARE PREDOMINANTLY CENTRAL MEMORY (>80%; CD4+/CD8+, CD62L+,

Common Name

English

Zamtocabtagene autoleucel [WHO-DD]

Common Name

English

Code System Code Type Description

FDA UNII

NT3BAN5MDV

Created by admin on Wed Apr 02 06:26:15 GMT 2025 , Edited by admin on Wed Apr 02 06:26:15 GMT 2025

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SMS_ID

300000007280

Created by admin on Wed Apr 02 06:26:15 GMT 2025 , Edited by admin on Wed Apr 02 06:26:15 GMT 2025

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NCI_THESAURUS

C180596

Created by admin on Wed Apr 02 06:26:15 GMT 2025 , Edited by admin on Wed Apr 02 06:26:15 GMT 2025

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INN

11574

Created by admin on Wed Apr 02 06:26:15 GMT 2025 , Edited by admin on Wed Apr 02 06:26:15 GMT 2025

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Related Record Type Details


					NT3BAN5MDV

ZAMTOCABTAGENE AUTOLEUCEL

ACTIVE MOIETY

Comments:

Antigen specific killing and cytokine secretion

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION			ZAMTOCABTAGENE AUTOLEUCEL VECTOR	GMG3GH6XRC
CULTURE	CD4+/CD8 ENRICHMENT	CELL SEPARATION

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					ZAMTOCABTAGENE AUTOLEUCEL EXPRESSED ANTI-CD20-CD19 CHIMERIC ANTIGEN RECEPTOR	FIF7L4K9BC
INSERTED GENE EXPRESSION VECTOR					ZAMTOCABTAGENE AUTOLEUCEL TRANSGENE INSERT	5CF9YS6GEV