ZAMTOCABTAGENE AUTOLEUCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 15:41:21 GMT 2023` Edited by `admin` on `Sat Dec 16 15:41:21 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Name	T CELLS
Record UNII	NT3BAN5MDV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZAMTOCABTAGENE AUTOLEUCEL

Official Name

English

zamtocabtagene autoleucel [INN]

Common Name

English

CELLS ARE ACTIVATED IN THE PRESENCE OF A COLLOIDAL POLYMERIC NANOMATRIX COVALENTLY ATTACHED TO ANTI-CD3 AND ANTI-CD28, TRANSDUCED, AND THEN CULTURED IN THE PRESENCE OF IL-7 AND IL-15. THE T CELLS ARE PREDOMINANTLY CENTRAL MEMORY (>80%; CD4+/CD8+, CD62L+,

Common Name

English

AUTOLOGOUS T CELLS OBTAINED FROM PERIPHERAL BLOOD COLLECTED BY LEUKAPHERESIS, TRANSDUCED WITH A NON-REPLICATING LENTIVIRAL VECTOR, PSEUDOTYPED WITH VESICULAR STOMATITIS VIRUS (VSV) GLYCOPROTEIN (G), ENCODING A CODON-OPTIMIZED CHIMERIC ANTIGEN RECEPTOR (C

Common Name

English

Code System Code Type Description

FDA UNII

NT3BAN5MDV

Created by admin on Sat Dec 16 15:41:21 GMT 2023 , Edited by admin on Sat Dec 16 15:41:21 GMT 2023

PRIMARY

NCI_THESAURUS

C180596

Created by admin on Sat Dec 16 15:41:21 GMT 2023 , Edited by admin on Sat Dec 16 15:41:21 GMT 2023

PRIMARY

INN

11574

Created by admin on Sat Dec 16 15:41:21 GMT 2023 , Edited by admin on Sat Dec 16 15:41:21 GMT 2023

PRIMARY

Related Record Type Details


					NT3BAN5MDV

ZAMTOCABTAGENE AUTOLEUCEL

ACTIVE MOIETY

Comments:

Antigen specific killing and cytokine secretion

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION			ZAMTOCABTAGENE AUTOLEUCEL VECTOR	GMG3GH6XRC
CULTURE	CD4+/CD8 ENRICHMENT	CELL SEPARATION

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					ZAMTOCABTAGENE AUTOLEUCEL EXPRESSED ANTI-CD20-CD19 CHIMERIC ANTIGEN RECEPTOR	FIF7L4K9BC
INSERTED GENE EXPRESSION VECTOR					ZAMTOCABTAGENE AUTOLEUCEL TRANSGENE INSERT	5CF9YS6GEV