OLEZARSEN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 18:33:01 GMT 2023` Edited by `admin` on `Sat Dec 16 18:33:01 GMT 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	NSY2BY6PSB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OLEZARSEN SODIUM

Official Name

English

ALL-P-AMBO-5'-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXYL))PHOSPHO)-2'-O-(2-METHOXYETHYL)-P-THIOADENYLYL-(3'-O->5'-O)-2'-O-(2-METHOXYETHYL)-P-THIOGUANYLYL-(3'

Systematic Name

English

ISIS-678354 SODIUM

Code

English

IONIS-APOCIII-LRX, SODIUM

Code

English

OLEZARSEN SODIUM [USAN]

Common Name

English

D(P-THIO)((2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M 5RU-M5C-T-T-G-T-M5C-M5C-A-G-M5C-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))

Systematic Name

English

Code System Code Type Description

FDA UNII

NSY2BY6PSB

Created by admin on Sat Dec 16 18:33:01 GMT 2023 , Edited by admin on Sat Dec 16 18:33:01 GMT 2023

PRIMARY

USAN

HI-30

Created by admin on Sat Dec 16 18:33:01 GMT 2023 , Edited by admin on Sat Dec 16 18:33:01 GMT 2023

PRIMARY

NCI_THESAURUS

C180653

Created by admin on Sat Dec 16 18:33:01 GMT 2023 , Edited by admin on Sat Dec 16 18:33:01 GMT 2023

PRIMARY

CAS

2298451-31-5

Created by admin on Sat Dec 16 18:33:01 GMT 2023 , Edited by admin on Sat Dec 16 18:33:01 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20
Deoxyribose (DNA)	1_6-1_15	10 / 20

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_20	19 / 19

Related Record Type Details


					S3RS2SA30L

OLEZARSEN

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_4] [1_5] [1_16] [1_17] [1_18] [1_20]	RESIDUE_SPECIFIC	URACIL	THYMINE	QR26YLT7LT
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS		UNSPECIFIED SUBSTANCE	38900c60 (not in database)
NUCLEOSIDE BASE SUBSTITUTION	[1_3] [1_6] [1_11] [1_12] [1_15]	RESIDUE_SPECIFIC	CYTOSINE	5-METHYLCYTOSINE	6R795CQT4H