Misitatug Blivedotin

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 19:09:04 GMT 2025` Edited by `admin` on `Wed Apr 02 19:09:04 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	NS5GTS5FLQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Misitatug Blivedotin

Official Name

English

H-gamma1 heavy chain (1-454) [VH Musmus/Homsap (Mus musculus IGHV4-1*02 (91.8%) -(IGHD) -IGHJ1*01 (100%)/Homo sapiens IGHV3-74*03 (80.6%) Q120>A (116), M123>T (119) -(IGHD) -IGHJ3*01 (85.7%), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens

Preferred Name

English

Immunoglobulin G1, anti-(human mesothelin) (human-Mus musculus monoclonal RC88 ?1-chain), disulfide with human-Mus musculus monoclonal RC88 ?-chain, dimer, reduced, cyclic bis(thioether) with N-methyl-N-[[[4-[[N-[2-[[3-oxo-3-[tetrahydro-3,5-bis(3-mercapt

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens MSLN (mesothelin, pre-pro-megakaryocyte-potentiating factor, megakaryocyte-potentiating factor, MPF, CAK1)]; conjugated on an average of 4 cysteinyl residues to monomethylauristatin E (MMAE), with a ratio of 1

Common Name

English

misitatug blivedotin [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000054745

Created by admin on Wed Apr 02 19:09:04 GMT 2025 , Edited by admin on Wed Apr 02 19:09:04 GMT 2025

PRIMARY

INN

12877

Created by admin on Wed Apr 02 19:09:04 GMT 2025 , Edited by admin on Wed Apr 02 19:09:04 GMT 2025

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CAS

2767203-06-3

Created by admin on Wed Apr 02 19:09:04 GMT 2025 , Edited by admin on Wed Apr 02 19:09:04 GMT 2025

PRIMARY

NCI_THESAURUS

C174395

Created by admin on Wed Apr 02 19:09:04 GMT 2025 , Edited by admin on Wed Apr 02 19:09:04 GMT 2025

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FDA UNII

NS5GTS5FLQ

Created by admin on Wed Apr 02 19:09:04 GMT 2025 , Edited by admin on Wed Apr 02 19:09:04 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_151	2_207
2_227	4_213
2_268	2_328
1_151	1_207
2_374	2_432
3_23	3_87
3_133	3_193
4_23	4_87
4_133	4_193
1_227	3_213
1_233	2_233
1_236	2_236
1_268	1_328
1_374	1_432

Glycosylation Link Type	Site
N	1_304
N	2_304

Related Record Type Details


					5BGF9D8YHK

Dicysteinyl blivedotin

CONJUGATE COMPONENT->CONJUGATE

Amount:


					X5F3Q2SE7P

Misitatug

CONJUGATE COMPONENT->CONJUGATE

Amount:


					X5F3Q2SE7P

Misitatug

PARENT -> DERIVATIVE

Amount:


					V7I58RC5EJ

MONOMETHYL AURISTATIN E

TOXIN -> CONJUGATE

Amount:


					J27WDC343N

TARGET->LIGAND

Amount:

Related Record Type Details


					NS5GTS5FLQ

Misitatug Blivedotin

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_227] [1_233] [1_236] [2_227] [2_233] [2_236] [3_213] [4_213]	SITE_SPECIFIC	C	Amount:	Dicysteinyl blivedotin	5BGF9D8YHK
AMINO ACID REMOVAL	[1_454] [2_454]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL