LODAPOLIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 00:11:35 GMT 2025` Edited by `admin` on `Wed Apr 02 00:11:35 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	NR4MAD6PPB
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LY-3300054

Preferred Name

English

LODAPOLIMAB

Official Name

English

Lodapolimab [WHO-DD]

Common Name

English

LODAPOLIMAB [USAN]

Common Name

English

IMMUNOGLOBULIN G1-LAMBDA, ANTI-(HOMO SAPIENS PROGRAMMED CELL DEATH 1 LIGAND 1 (PROGRAMMED DEATH LIGAND 1, B7 HOMOLOG 1, PD-L1, CD274 ANTIGEN)) HUMAN MONOCLONAL ANTIBODY .GAMMA.1 HEAVY CHAIN (1-453) (HOMO SAPIENS VH (IGHV1-69*06(IGHD)-IGHJ6*01 (8.8.16) (1

Systematic Name

English

lodapolimab [INN]

Common Name

English

IMMUNOGLOBULIN G1 (240-ALANINE, 241-GLUTAMIC ACID, 243-ALANINE, 336-SERINE, 337-SERINE), ANTI-(HUMAN PROGRAMMED DEATH-LIGAND 1) (HUMAN MONOCLONAL LY3300054 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL LY3300054 .LAMBDA.-CHAIN, DIMER

Systematic Name

English

LY3300054, A FULLY HUMAN IGG1.LAMBDA. ANTI-PD-L1 MONOCLONAL ANTIBODY

Common Name

English

LY3300054

Code

English

Code System Code Type Description

SMS_ID

300000010810

Created by admin on Wed Apr 02 00:11:35 GMT 2025 , Edited by admin on Wed Apr 02 00:11:35 GMT 2025

PRIMARY

USAN

FG-118

Created by admin on Wed Apr 02 00:11:35 GMT 2025 , Edited by admin on Wed Apr 02 00:11:35 GMT 2025

PRIMARY

INN

11185

Created by admin on Wed Apr 02 00:11:35 GMT 2025 , Edited by admin on Wed Apr 02 00:11:35 GMT 2025

PRIMARY

NCI_THESAURUS

C128138

Created by admin on Wed Apr 02 00:11:35 GMT 2025 , Edited by admin on Wed Apr 02 00:11:35 GMT 2025

PRIMARY

FDA UNII

NR4MAD6PPB

Created by admin on Wed Apr 02 00:11:35 GMT 2025 , Edited by admin on Wed Apr 02 00:11:35 GMT 2025

PRIMARY

CAS

2118349-31-6

Created by admin on Wed Apr 02 00:11:35 GMT 2025 , Edited by admin on Wed Apr 02 00:11:35 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_150	2_206
2_226	4_215
2_267	2_327
1_150	1_206
2_373	2_431
3_22	3_89
3_138	3_197
4_22	4_89
4_138	4_197
1_226	3_215
1_232	2_232
1_235	2_235
1_267	1_327
1_373	1_431

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_303
N	2_303

Related Record Type Details


					L4766ELH5T

PROGRAMMED CELL DEATH 1 LIGAND 1

TARGET -> INHIBITOR

Related Record Type Details


					NR4MAD6PPB

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[3_14] [3_41] [4_14] [4_41]	SITE_SPECIFIC			HYDROXYPROLINE	RMB44WO89X
AMINO_ACID_SUBSTITUTION	[1_1] [2_1] [3_1] [4_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL