GAVOCABTAGENE AUTOLEUCEL

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 13:40:10 GMT 2025` Edited by `admin` on `Wed Apr 02 13:40:10 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	t cells
Record UNII	NP6CFH3G8H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TC-210 T CELLS

Preferred Name

English

GAVOCABTAGENE AUTOLEUCEL

Official Name

English

AUTOLOGOUS T CELLS TRANSDUCED EX VIVO WITH A NON-REPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING AN ANTI-MESOTHELIN (MSLN) SINGLE-DOMAIN ANTIBODY (SDAB) BASED CHIMERIC ANTIGEN RECEPTOR WITH A LEADER SEQUENCE DERIVED FROM GRANULOCYTE-MACR

Common Name

English

Gavocabtagene autoleucel [WHO-DD]

Common Name

English

GAVOCABTAGENE AUTOLEUCEL [USAN]

Common Name

English

gavocabtagene autoleucel [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

689519

Created by admin on Wed Apr 02 13:40:10 GMT 2025 , Edited by admin on Wed Apr 02 13:40:10 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C160780

Created by admin on Wed Apr 02 13:40:10 GMT 2025 , Edited by admin on Wed Apr 02 13:40:10 GMT 2025

PRIMARY

FDA UNII

NP6CFH3G8H

Created by admin on Wed Apr 02 13:40:10 GMT 2025 , Edited by admin on Wed Apr 02 13:40:10 GMT 2025

PRIMARY

USAN

JK-123

Created by admin on Wed Apr 02 13:40:10 GMT 2025 , Edited by admin on Wed Apr 02 13:40:10 GMT 2025

PRIMARY

SMS_ID

300000028851

Created by admin on Wed Apr 02 13:40:10 GMT 2025 , Edited by admin on Wed Apr 02 13:40:10 GMT 2025

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INN

11437

Created by admin on Wed Apr 02 13:40:10 GMT 2025 , Edited by admin on Wed Apr 02 13:40:10 GMT 2025

PRIMARY

Related Record Type Details


					J27WDC343N

TARGET->CYTOTOXIC T-CELL

Comments:

Mesothelin is overexpressed in multiple cancers, including more than 90% of mesotheliomas and pancreatic adenocarcinomas, approximately 70% of ovarian cancers, and 50% of lung adenocarcinomas, among others

Amount:

Related Record Type Details


					NP6CFH3G8H

GAVOCABTAGENE AUTOLEUCEL

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
LENTIVIRAL TRANSFECTION	TRANSFECTION			GAVOCABTAGENE AUTOLEUCEL LENTIVIRAL VECTOR	99PW2Y4WZ2

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					GAVOCABTAGENE AUTOLEUCEL CHIMERIC ANTIGEN RECEPTOR PREPROTEIN	B5KGT2Q7FN
INSERTED GENE EXPRESSION VECTOR					UNSPECIFIED SUBSTANCE	ddd0c12f (not in database)
VECTOR EXPRESSED PROTEIN					GAVOCABTAGENE AUTOLEUCEL CHIMERIC ANTIGEN RECEPTOR	7NH8H58KJG