AUTOLOGOUS T CELLS TRANSDUCED EX VIVO WITH A NON-REPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING AN ANTI-MESOTHELIN (MSLN) SINGLE-DOMAIN ANTIBODY (SDAB) BASED CHIMERIC ANTIGEN RECEPTOR WITH A LEADER SEQUENCE DERIVED FROM GRANULOCYTE-MACR
Mesothelin is overexpressed in multiple cancers, including more than 90% of mesotheliomas and pancreatic adenocarcinomas, approximately 70% of ovarian cancers, and 50% of lung adenocarcinomas, among others
