Details
Stereochemistry | RACEMIC |
Molecular Formula | C20H20N2O.C4H4O4 |
Molecular Weight | 420.4578 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C/C(O)=O.OC1CCCC2=NC3=C(C=CC=C3)C(NCC4=CC=CC=C4)=C12
InChI
InChIKey=JRQSVNSUJOFXHC-BTJKTKAUSA-N
InChI=1S/C20H20N2O.C4H4O4/c23-18-12-6-11-17-19(18)20(15-9-4-5-10-16(15)22-17)21-13-14-7-2-1-3-8-14;5-3(6)1-2-4(7)8/h1-5,7-10,18,23H,6,11-13H2,(H,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1-
Molecular Formula | C4H4O4 |
Molecular Weight | 116.0722 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Optical Activity | NONE |
Molecular Formula | C20H20N2O |
Molecular Weight | 304.3856 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Suronacrine (also known as HP128) is a tetrahydroacridinol derivative patented by Hoechst-Roussel Pharmaceuticals, Inc for the treatment of various memory dysfunctions characterized by decreased cholinergic function. The activity ofHP128 is attributable to its inhibition of both norepinephrine uptake and cholinesterase enzyme activity. Suronacrine has enhanced memory in animals with combined cholinergic and adrenergic lesions. In preclinical models, Suronacrine blocks responses to nerve stimulation and to carbachol, but increased responses to acetylcholine. Extracellular recording of nerve terminal currents from triangularis sterni preparations revealed that Suronacrine had a selective blocking action on the waveform associated with K+ currents.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1776748
100 mg twice daily
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:44:10 GMT 2023
by
admin
on
Fri Dec 15 17:44:10 GMT 2023
|
Record UNII |
NO3H145KZO
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C47792
Created by
admin on Fri Dec 15 17:44:10 GMT 2023 , Edited by admin on Fri Dec 15 17:44:10 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
CHEMBL301958
Created by
admin on Fri Dec 15 17:44:10 GMT 2023 , Edited by admin on Fri Dec 15 17:44:10 GMT 2023
|
PRIMARY | |||
|
NO3H145KZO
Created by
admin on Fri Dec 15 17:44:10 GMT 2023 , Edited by admin on Fri Dec 15 17:44:10 GMT 2023
|
PRIMARY | |||
|
AA-65
Created by
admin on Fri Dec 15 17:44:10 GMT 2023 , Edited by admin on Fri Dec 15 17:44:10 GMT 2023
|
PRIMARY | |||
|
C96776
Created by
admin on Fri Dec 15 17:44:10 GMT 2023 , Edited by admin on Fri Dec 15 17:44:10 GMT 2023
|
PRIMARY | |||
|
C070061
Created by
admin on Fri Dec 15 17:44:10 GMT 2023 , Edited by admin on Fri Dec 15 17:44:10 GMT 2023
|
PRIMARY | |||
|
9953907
Created by
admin on Fri Dec 15 17:44:10 GMT 2023 , Edited by admin on Fri Dec 15 17:44:10 GMT 2023
|
PRIMARY | |||
|
113108-86-4
Created by
admin on Fri Dec 15 17:44:10 GMT 2023 , Edited by admin on Fri Dec 15 17:44:10 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |