U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Approval Year

Substance Class Structurally Diverse
Created
by admin
on Wed Apr 02 18:15:34 GMT 2025
Edited
by admin
on Wed Apr 02 18:15:34 GMT 2025
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part blood
Fraction Name t cells, monocytes, nk cells, or b cells
Record UNII
NKC6YR89C7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Remvulimorgene Autoleucel
INN  
Official Name English
autologous peripheral blood mononuclear cells (PBMCs) obtained by apheresis and engineered into enhanced antigen presenting cells (eAPCs) by loading with five messenger RNAs (mRNAs) individually encoding human papillomavirus type 16 (HPV16) E6 protein, H
Preferred Name English
remvulimorgene autoleucel [INN]
Common Name English
Code System Code Type Description
SMS_ID
300000056442
Created by admin on Wed Apr 02 18:15:35 GMT 2025 , Edited by admin on Wed Apr 02 18:15:35 GMT 2025
PRIMARY
INN
12777
Created by admin on Wed Apr 02 18:15:35 GMT 2025 , Edited by admin on Wed Apr 02 18:15:35 GMT 2025
PRIMARY
FDA UNII
NKC6YR89C7
Created by admin on Wed Apr 02 18:15:35 GMT 2025 , Edited by admin on Wed Apr 02 18:15:35 GMT 2025
PRIMARY
NCI_THESAURUS
C206977
Created by admin on Wed Apr 02 18:15:35 GMT 2025 , Edited by admin on Wed Apr 02 18:15:35 GMT 2025
PRIMARY
Related Record Type Details
TARGET ORGANISM->VACCINE ANTIGEN
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
Cell Squeeze Process GENE ADDITION mbIL-2 mRNA (mRNA for the membrane bound human IL-2) L2S9NE5V6V
Cell Squeeze Process GENE ADDITION HPV16 E6 mRNA 6N4MV78HNX
Cell Squeeze Process GENE ADDITION CD86 mRNA (mRNA for the human CD86 protein) Z9VX6HD5TY
Cell Squeeze Process GENE ADDITION mbIL-12 mRNA (mRNA for the membrane bound human IL-12) EA585K5UYN
Cell Squeeze Process GENE ADDITION HPV16 E7 mRNA E688CZ7WZD

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN HUMAN PAPILLOMAVIRUS TYPE 16 PROTEIN E7 NQK5L7WE48
VECTOR EXPRESSED PROTEIN PROTEIN E6 (HUMAN PAPILLOMAVIRUS TYPE 16) 9Z6229JXZ6
VECTOR EXPRESSED PROTEIN T-LYMPHOCYTE ACTIVATION ANTIGEN CD86 3S33IH52EL
VECTOR EXPRESSED PROTEIN mbIL-2 mRNA encoded fusion protein of the transmembrane portion of the transferrin receptor and the cytokine IL-2 linked by a glycine (G) serine (S) motif D7G89L3KE3
VECTOR EXPRESSED PROTEIN mbIL-12 mRNA encoded fusion protein of the transmembrane portion of the transferrin receptor and the cytokine IL-12 linked by a glycine (G) serine (S) motif J3AW84Q5DC
Name Property Type Amount Referenced Substance Defining Parameters References
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN EXPRESSED CHEMICAL
ANTIGEN EXPRESSED CHEMICAL
ANTIGEN EXPRESSED BIOLOGICAL