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Details

Stereochemistry ACHIRAL
Molecular Formula 2C2H8N2.Cu
Molecular Weight 183.743
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of CUPRIC ETHYLENEDIAMINE

SMILES

[Cu++].NCCN.NCCN

InChI

InChIKey=ATSGLBOJGVTHHC-UHFFFAOYSA-N
InChI=1S/2C2H8N2.Cu/c2*3-1-2-4;/h2*1-4H2;/q;;+2

HIDE SMILES / InChI
Molecular Formula Cu
Molecular Weight 63.546
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C2H8N2
Molecular Weight 60.0983
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/9735163 | https://www.ncbi.nlm.nih.gov/pubmed/1667723 | Pohanish, R.P. (2011) "Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens", p.790 Retrieved from https://books.google.ru/books?id=RYt0Wzb60b4C

CUPRIC ETHYLENEDIAMINE is a purple liquid with an ammoniacal odor. It is used to dissolve cellulose products to give a cuprammonium-type solution. Superoxide ion is generated as an intermediate at the first reaction step between CUPRIC ETHYLENEDIAMINE and H2O2. DNA strand scission may be caused by hydroxyl radicals generated from the reaction of CUPRIC ETHYLENEDIAMINE with biological reductants under aerobic conditions. Since ascorbic acid, is present in living cells, CUPRIC ETHYLENEDIAMINE may be capable of initiating DNA damage in the presence of this reductant. Inhalation of vapor CUPRIC ETHYLENEDIAMINE irritates mucous membrane and may cause asthma. Liquid causes severe irritation of eyes and possible corneal injury. Contact with skin causes irritation. Ingestion causes irritation of mouth and stomach.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
DNA
278
Target ID: CHEMBL2311221
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Evidence for the formation of superoxide ion from the reaction of Cu(II)-ethylenediamine complex with hydrogen peroxide.
1991 Nov
Reactive oxygen species generated from the reaction of copper(II) complexes with biological reductants cause DNA strand scission.
1998 Sep 15
Patents

Patents

US2952550 A
1
US2999757 A
1
US3017316 A
1
US3124503 A
1
US3135613 A
1
US3433663 A
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Cupriethylene diamine (0.25 mM) plus hydroquinone did not cause any DNA strand scission, irrespective of the concentration of hydroquinone used (0.25, 0.5, 1.25, 2.5 mM).
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:52:57 GMT 2023
Edited
by admin
on Sat Dec 16 08:52:57 GMT 2023
Record UNII
NIP4I4LVCC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CUPRIC ETHYLENEDIAMINE
Common Name English
BIS(ETHYLENEDIAMINE)COPPER(2+) ION
Common Name English
COPPER-ETHYLENEDIAMINE COMPLEX
Common Name English
COPPER(2+), BIS(ETHYLENEDIAMINE)-, ION
Systematic Name English
BIS(ETHYLENEDIAMINE)COPPER(2+)
Common Name English
BIS(1,2-ETHANEDIAMINE-N,N')COPPER(2+) [HSDB]
Common Name English
BIS(ETHYLENEDIAMINE)COPPER(II)
Common Name English
ETHANE, 1,2-DIAMINO-, COPPER COMPLEX
Systematic Name English
COPPER(2+), BIS(1,2-ETHANEDIAMINE-.KAPPA.N,.KAPPA.N')-, (SP-4-1)-
Systematic Name English
COPPER(2+), BIS(1,2-ETHANEDIAMINE-N,N')-, (SP-4-1)-
Systematic Name English
BIS(ETHYLENEDIAMINE)COPPER ION
Common Name English
CUPRIETHYLENE DIAMINE
Common Name English
CUPRIETHYLENEDIAMINE, BIS(ETHYLENEDIAMINE)-, ION
Systematic Name English
COPPER(2+), BIS(1,2-ETHANEDIAMINE-.KAPPA.N1,.KAPPA.N2)-, (SP-4-1)-
Systematic Name English
CUPRIETHYLENEDIAMINE
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 24407
Created by admin on Sat Dec 16 08:52:57 GMT 2023 , Edited by admin on Sat Dec 16 08:52:57 GMT 2023
Code System Code Type Description
PUBCHEM
3032609
Created by admin on Sat Dec 16 08:52:57 GMT 2023 , Edited by admin on Sat Dec 16 08:52:57 GMT 2023
PRIMARY
FDA UNII
NIP4I4LVCC
Created by admin on Sat Dec 16 08:52:57 GMT 2023 , Edited by admin on Sat Dec 16 08:52:57 GMT 2023
PRIMARY
HSDB
2767
Created by admin on Sat Dec 16 08:52:57 GMT 2023 , Edited by admin on Sat Dec 16 08:52:57 GMT 2023
PRIMARY
CAS
13426-91-0
Created by admin on Sat Dec 16 08:52:57 GMT 2023 , Edited by admin on Sat Dec 16 08:52:57 GMT 2023
PRIMARY
NIH
NCATS
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