Details
Stereochemistry | RACEMIC |
Molecular Formula | C13H18ClNO2.ClH |
Molecular Weight | 292.201 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(N)C(=O)OC(C)(C)CC1=CC=C(Cl)C=C1
InChI
InChIKey=OPAKSOWFKIUFNP-UHFFFAOYSA-N
InChI=1S/C13H18ClNO2.ClH/c1-9(15)12(16)17-13(2,3)8-10-4-6-11(14)7-5-10;/h4-7,9H,8,15H2,1-3H3;1H
Molecular Formula | C13H18ClNO2 |
Molecular Weight | 255.741 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Alaproclate is a selective 5-HT uptake inhibitor. Alaproclate enantiomers block potassium and NMDA receptor currents in a stereoselective manner. Alaproclate was practically devoid of action on a number of receptors as examined in binding studies in vitro: 5-HT, histamine-H1, alpha 1, -alpha 2-adrenergic and dopamine D2 receptors. Alaproclate was investigated in trials for the treatment of depression and dementia.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1907608 |
0.3 µM [IC50] | ||
Target ID: GO:0051610 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7996440 |
PubMed
Title | Date | PubMed |
---|---|---|
Endogenous activation of serotonin-2A receptors is required for respiratory rhythm generation in vitro. | 2002 Dec 15 |
|
Cocaine-induced brain activation determined by positron emission tomography neuroimaging in conscious rhesus monkeys. | 2002 Jan |
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Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys. | 2002 Mar |
|
Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats. | 2003 Feb |
|
Open space swimming test to index antidepressant activity. | 2003 Jun 15 |
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Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats. | 2003 Nov |
|
Inhibitory actions of serotonin on glutamate release in dorsal medulla suppress systemic arterial pressure of cats. | 2004 Jan 23 |
|
Serotonin reuptake inhibitors do not prevent 5,7-dihydroxytryptamine-induced depletion of serotonin in rat brain. | 2004 May 8 |
|
Tamoxifen's protection against breast cancer recurrence is not reduced by concurrent use of the SSRI citalopram. | 2008 Aug 19 |
|
Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration. | 2008 Oct 2 |
|
Chronic fluoxetine treatment increases daytime melatonin synthesis in the rodent. | 2009 |
|
Effects of serotonergic agents on survival and hemolymph composition of the larval mosquito Aedes aegypti (Diptera: Culicidae, L.) in vivo: does serotonin regulate hemolymph acid-base homeostasis? | 2009 Nov |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:49:59 GMT 2023
by
admin
on
Sat Dec 16 09:49:59 GMT 2023
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Record UNII |
NIH506S9US
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Record Status |
Validated (UNII)
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Record Version |
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DTXSID80976158
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11957454
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60719-83-7
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DBSALT002575
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NIH506S9US
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Related Record | Type | Details | ||
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ENANTIOMER -> RACEMATE | |||
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ENANTIOMER -> RACEMATE |