Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H21NO2 |
| Molecular Weight | 295.3755 |
| Optical Activity | ( - ) |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC3=CC=C(O)C(O)=C3C4=C1C(CCN2CCC)=CC=C4
InChI
InChIKey=BTGAJCKRXPNBFI-OAHLLOKOSA-N
InChI=1S/C19H21NO2/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14/h3-7,15,21-22H,2,8-11H2,1H3/t15-/m1/s1
| Molecular Formula | C19H21NO2 |
| Molecular Weight | 295.3755 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Propylnorapomorphine is a potent and selective D2 receptor agonist. Propylnorapomorphine is used as a tool compound to label dopamine receptors in rodent brain, and elicits dopaminergic behavioural effects. It stimulates motor activity, induces stereotypic behaviour and sexual stimulation. Propylnorapomorphine was investigated in clinical trial against Parkinson's disease and schizophrenia
CNS Activity
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL217 |
10.12 null [pKi] | ||
Target ID: CHEMBL234 |
8.74 null [pKi] | ||
Target ID: P14416 Gene ID: 1813.0 Gene Symbol: DRD2 Target Organism: Homo sapiens (Human) |
|||
Target ID: P35462 Gene ID: 1814.0 Gene Symbol: DRD3 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in rat brain. | 1976 Jan |
|
| 3H-N-n-propylnorapomorphine: a novel agonist ligand for central dopamine receptors. | 1979 Jul 1 |
|
| Potentiation of the aphrodisiac effect of N-n-propyl-norapomorphine by naloxone. | 1982 Jul 9 |
|
| Behavioral effects of (-)10,11-methylenedioxy-N-n-propylnoraporphine, an orally effective long-acting agent active at central dopamine receptors, and analogous aporphines. | 1982 Oct |
|
| Kinetics of the uptake and distribution of the dopamine D(2,3) agonist (R)-N-[1-(11)C]n-propylnorapomorphine in brain of healthy and MPTP-treated Göttingen miniature pigs. | 2003 Jul |
|
| Effects of unilateral 6-OHDA lesions on [3H]-N-propylnorapomorphine binding in striatum ex vivo and vulnerability to amphetamine-evoked dopamine release in rat. | 2011 Feb |
|
| Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D₂/₃ receptors in their high-affinity state. | 2014 Jan 23 |
Patents
Sample Use Guides
In a clinical study against Parkinson's disease, propylnorapomorphine was administered orally. The most effect was observed at doses of 10 to 15 mg six time per day. In rodents, propylnorapomorphine is administered intraperitoneally.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 15:02:03 GMT 2023
by
admin
on
Sat Dec 16 15:02:03 GMT 2023
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| Record UNII |
NH381P1BR8
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| Record Status |
Validated (UNII)
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| Record Version |
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18426-20-5
Created by
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NH381P1BR8
Created by
admin on Sat Dec 16 15:02:03 GMT 2023 , Edited by admin on Sat Dec 16 15:02:03 GMT 2023
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167715
Created by
admin on Sat Dec 16 15:02:03 GMT 2023 , Edited by admin on Sat Dec 16 15:02:03 GMT 2023
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RACEMATE -> ENANTIOMER |
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SALT/SOLVATE -> PARENT | |||
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LABELED -> NON-LABELED |
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ACTIVE MOIETY |
