Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H23N3O2 |
| Molecular Weight | 325.4048 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H]1NC(=O)[C@H](CC2=C(NC3=C2C=CC=C3)C(C)(C)C=C)NC1=O
InChI
InChIKey=LVPZJIGICMPWFH-NHYWBVRUSA-N
InChI=1S/C19H23N3O2/c1-5-19(3,4)16-13(12-8-6-7-9-14(12)21-16)10-15-18(24)20-11(2)17(23)22-15/h5-9,11,15,21H,1,10H2,2-4H3,(H,20,24)(H,22,23)/t11-,15-/m0/s1
| Molecular Formula | C19H23N3O2 |
| Molecular Weight | 325.4048 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Aspergillus fungi are important producers of metabolites with toxic potential; they can produce a wide variety of secondary metabolites one of which is preechinulin. It was shown, that this compound failed to protect cells against NO toxicity or induce these alterations, suggesting their link with the cytoprotective mechanism.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Taxonomic Characterization and Secondary Metabolite Profiling of Aspergillus Section Aspergillus Contaminating Feeds and Feedstuffs. | 2015-09-02 |
|
| Neoechinulin a imparts resistance to acute nitrosative stress in PC12 cells: a potential link of an elevated cellular reserve capacity for pyridine nucleotide redox turnover with cytoprotection. | 2012 |
|
| Isolation of talathermophilins from the thermophilic fungus Talaromyces thermophilus YM3-4. | 2011-10-28 |
Sample Use Guides
Cells in 6-well plates were incubated with preechinulin (each 100 µmol/L) or their vehicle (0.1% DMSO) for the indicated times, and GSH content in the cells was measured. Preechinulin failed to protect cells against NO toxicity or induce these alterations, suggesting their link with the cytoprotective mechanism.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:09:23 GMT 2025
by
admin
on
Mon Mar 31 23:09:23 GMT 2025
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| Record UNII |
NFA24NXF2J
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| Record Status |
Validated (UNII)
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| Record Version |
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NFA24NXF2J
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44445554
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admin on Mon Mar 31 23:09:23 GMT 2025 , Edited by admin on Mon Mar 31 23:09:23 GMT 2025
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