N-(1,3-BIS(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL)-N,N'-BIS(HYDROXYMETHYL)UREA

Details

Stereochemistry	RACEMIC
Molecular Formula	C8H14N4O7
Molecular Weight	278.2194
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of N-(1,3-BIS(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL)-N,N'-BIS(HYDROXYMETHYL)UREA

Structure Search

SMILES

OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O

InChI

InChIKey=SOROIESOUPGGFO-UHFFFAOYSA-N

InChI=1S/C8H14N4O7/c13-1-9-7(18)10(2-14)5-6(17)12(4-16)8(19)11(5)3-15/h5,13-16H,1-4H2,(H,9,18)

HIDE SMILES / InChI

Molecular Formula	C8H14N4O7
Molecular Weight	278.2194
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17725923 | https://www.ncbi.nlm.nih.gov/pubmed/19580920

Diazolidinylurea is a broad-spectrum antimicrobial preservative used in cosmetics and pharmaceutical preparations. It is especially active against gram-negative bacteria and is often combined with parabens. Diazolidinylurea is the most active member of the imidazolidinyl urea group, that acts as a formaldehyde releasers. Diazolidinylurea is used in many cosmetics, skin care products, shampoos, and conditioners, as well as a wide range of products including bubble baths, baby wipes, and household detergents.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: http://www.sunpubc.com/en/index.php?optionid=672&auto_id=300 http://www.chemicalbook.com/ChemicalProductProperty_EN_CB2158514.htm	Inactive ingredient		Approved 8583	Pain Relief Cream by ALLURE LABS INC. Approved Use Topical Analgesic Uses: For the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, strains, sprains and bruises. Launch Date 2017

Doses

Dose	Population	Adverse events
6000 mg/m2 single, topical Highest studied dose Dose: 6000 mg/m2 Route: topical Route: single Dose: 6000 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/11422263/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/11422263/	Sources: https://pubmed.ncbi.nlm.nih.gov/11422263/

PubMed

Title	Date	PubMed
ROAT: morphology of ROAT on arm, neck and face in formaldehyde and diazolidinyl urea sensitive individuals.	2006-01	16426289
[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].	2004-05	15218738

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:50:22 GMT 2025` Edited by `admin` on `Mon Mar 31 18:50:22 GMT 2025`
Record UNII	N9VX1IBW6K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N,N'-BIS(HYDROXYMETHYL)-N'-(1,3-BIS(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL)UREA

Preferred Name

English

N-(1,3-BIS(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL)-N,N'-BIS(HYDROXYMETHYL)UREA

Systematic Name

English

UREA, N-(1,3-BIS(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL)-N,N'-BIS(HYDROXYMETHYL)-

Systematic Name

English

N-HYDROXYMETHYL-N-(1,3-DI(HYDROXYMETHYL)-2,5-DIOXOIMIDAZOLIDIN-4-YL)-N'-HYDROXY-METHYLUREA

Systematic Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

128971