AMIBEGRON HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H26ClNO4.ClH
Molecular Weight	440.36
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCOC(=O)COC1=CC2=C(CC[C@@H](C2)NC[C@H](O)C3=CC=CC(Cl)=C3)C=C1

InChI

InChIKey=NQIZCDQCNYCVAS-RQBPZYBGSA-N

InChI=1S/C22H26ClNO4.ClH/c1-2-27-22(26)14-28-20-9-7-15-6-8-19(11-17(15)12-20)24-13-21(25)16-4-3-5-18(23)10-16;/h3-5,7,9-10,12,19,21,24-25H,2,6,8,11,13-14H2,1H3;1H/t19-,21-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C22H26ClNO4
Molecular Weight	403.899
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://adisinsight.springer.com/drugs/800001600
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/1976401 | https://www.ncbi.nlm.nih.gov/pubmed/14584972

Amibegron (SR 58611A or SR 58611) is a highly selective agonist for atypical beta3-adrenoceptors. It stimulates neuronal activity in a specific area of the prefrontal cortex and also inhibits intestinal motility. Amibegron was in phase III trials worldwide for the treatment of depression and generalised anxiety disorder but development of the product was discontinued in 2008. Amibegron has been tested for its potential as a treatment for irritable bowel syndrome.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Beta-3 adrenergic receptor 49 Target ID: CHEMBL246 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1976401 \| https://www.ncbi.nlm.nih.gov/pubmed/14584972	Agonist 2637

Conditions

Condition	Modality	Targets	Highest Phase	Product
Major depressive disorder 172 Sources: http://adisinsight.springer.com/drugs/800001600	Primary		Phase III 651	Unknown Approved Use Unknown
Generalized anxiety disorder 30 Sources: http://adisinsight.springer.com/drugs/800001600	Primary		Phase III 651	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
1PlusChem LLC	1P0015P5	https://www.1pchem.com/search?query=1P0015P5
ApexBio Technology	B7558	https://www.apexbt.com/catalogsearch/result/?q=B7558
Cayman Chemical	11954	http://www.caymanchem.com/app/template/Product.vm/catalog/11954
Chem Scene	CS-0025298	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-0025298
MolPort	MolPort-023-277-019	https://www.molport.com/shop/molecule-link/MolPort-023-277-019
MuseChem	I002159	https://www.musechem.com/product/I002159.html
Tocris	3986	https://www.tocris.com/search.php?Type=QuickSearch&Value=3986
Toronto Research Chemicals	S684445	https://www.trc-canada.com/product-detail/?CatNum=S684445
eMolecules	36500859	https://orderbb.emolecules.com/search/#?query=36500859

PubMed

Title	Date	PubMed
In vitro inhibition of intestinal motility by phenylethanolaminotetralines: evidence of atypical beta-adrenoceptors in rat colon.	1990 Aug	1976401
Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression.	2008 Jun	18358519

Patents

Sample Use Guides

In Vivo Use Guide

This eight week double-blind phase III trial compared the efficacy of paroxetine with two fixed doses of amibegron (175mg or 350mg q12) in treating the symptoms of depression (NCT00385307). In 24 healthy obese volunteers, amibegron 60 and 180 mg/day tid for 6 days and a single dose on day 7 was safe and well tolerated.

Route of Administration: Oral

In Vitro Use Guide

Amibegron (SR 58611A or SR 58611) increased cyclic AMP levels in membrane homogenates from rat interscapular brown adipose tissue with an EC50 of 20 nM. This compound also stimulated glycerol release from the brown fat cells, with an EC50 of 11 nM.

Substance Class	Chemical Created by `admin` on `Fri Dec 16 18:06:15 UTC 2022` Edited by `admin` on `Fri Dec 16 18:06:15 UTC 2022`
Record UNII	N910CJ679E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMIBEGRON HYDROCHLORIDE

Official Name

English

SR-58611A

Code

English

SR58611A

Code

English

Ethyl {[(7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}acetate hydrochloride

Systematic Name

English

AMIBEGRON HCL

Common Name

English

ACETIC ACID, (((7S)-7-(((2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO)-5,6,7,8-TETRAHYDRO-2-NAPHTHALENYL)OXY)-, ETHYL ESTER, HYDROCHLORIDE

Common Name

English

AMIBEGRON HYDROCHLORIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C48149