AMAFOLONE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H31NO2
Molecular Weight	305.4549
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](N)[C@@H](O)C[C@]34C)[C@@H]1CCC2=O

InChI

InChIKey=QPRBHGIRKWZUFJ-PPMYXAGCSA-N

InChI=1S/C19H31NO2/c1-18-8-7-14-12(13(18)5-6-17(18)22)4-3-11-9-15(20)16(21)10-19(11,14)2/h11-16,21H,3-10,20H2,1-2H3/t11-,12-,13-,14-,15-,16-,18-,19-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H31NO2
Molecular Weight	305.4549
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7026350 | https://www.ncbi.nlm.nih.gov/pubmed/2413942

Amafolone (ORG 6001) is an aminosteroid with antiarrhythmic properties. In concentrations which inhibit the inward Na+ current it exhibits calcium channel blocking properties.

Originator

Approval Year

PubMed

Title	Date	PubMed
Antiarrhythmic and hemodynamic effects of an aminosteroid (Org 3001) in the digitalized dog.	1976-03	1261591

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:18:25 GMT 2025` Edited by `admin` on `Wed Apr 02 08:18:25 GMT 2025`
Record UNII	N8Y78OKP8D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

amafolone [INN]

Preferred Name

English

AMAFOLONE

Official Name

English

3.ALPHA.-AMINO-2.BETA.-HYDROXY-5.ALPHA.-ANDROSTAN-17-ONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793