AMAFOLONE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H31NO2
Molecular Weight	305.4549
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])CC[C@@]4([H])C[C@H](N)[C@@H](O)C[C@]34C

InChI

InChIKey=QPRBHGIRKWZUFJ-PPMYXAGCSA-N

InChI=1S/C19H31NO2/c1-18-8-7-14-12(13(18)5-6-17(18)22)4-3-11-9-15(20)16(21)10-19(11,14)2/h11-16,21H,3-10,20H2,1-2H3/t11-,12-,13-,14-,15-,16-,18-,19-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H31NO2
Molecular Weight	305.4549
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7026350 | https://www.ncbi.nlm.nih.gov/pubmed/2413942

Amafolone (ORG 6001) is an aminosteroid with antiarrhythmic properties. In concentrations which inhibit the inward Na+ current it exhibits calcium channel blocking properties.

Originator

Approval Year

PubMed

Title	Date	PubMed
Antiarrhythmic and hemodynamic effects of an aminosteroid (Org 3001) in the digitalized dog.	1976 Mar	1261591

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:42:33 GMT 2023` Edited by `admin` on `Sat Dec 16 16:42:33 GMT 2023`
Record UNII	N8Y78OKP8D
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AMAFOLONE

Official Name

English

amafolone [INN]

Common Name

English

3.ALPHA.-AMINO-2.BETA.-HYDROXY-5.ALPHA.-ANDROSTAN-17-ONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793