ITAZIGREL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H14F3NO2S
Molecular Weight	365.369
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C2=C(N=C(S2)C(F)(F)F)C3=CC=C(OC)C=C3

InChI

InChIKey=CIPBQTCSXVEDSG-UHFFFAOYSA-N

InChI=1S/C18H14F3NO2S/c1-23-13-7-3-11(4-8-13)15-16(25-17(22-15)18(19,20)21)12-5-9-14(24-2)10-6-12/h3-10H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C18H14F3NO2S
Molecular Weight	365.369
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7101238

ITAZIGREL, a thiazole derivative, is a potent platelet aggregation inhibitor.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
platelet aggregation 80 Target ID: GO:0070527 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7101238	Inhibitor 8504

PubMed

Title	Date	PubMed
Medial smooth muscle cell proliferation in the balloon injured rabbit aorta: effect of a thiazole compound with platelet inhibitory activity.	1984-02-28	6719391
A thiazole compound with potential antithrombotic activity.	1982-04-30	7101238
Synthesis and platelet aggregation inhibitory activity of 4,5-bis(aryl)-2-substituted-thiazoles.	1981-12	7310827

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:41:56 GMT 2025` Edited by `admin` on `Mon Mar 31 18:41:56 GMT 2025`
Record UNII	N835I8CXY0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ITAZIGREL

Official Name

English

U-53,059

Preferred Name

English

itazigrel [INN]

Common Name

English

THIAZOLE, 4,5-BIS(4-METHOXYPHENYL)-2-(TRIFLUOROMETHYL)-

Systematic Name

English

ITAZIGREL [USAN]

Common Name

English

4,5-BIS(P-METHOXYPHENYL)-2-(TRIFLUOROMETHYL)THIAZOLE

Common Name

English

U-53059

Code

English

4,5-bis(4-Methoxyphenyl)-2-(trifluoromethyl)thiazole

Systematic Name

English

Code System Code Type Description

FDA UNII

N835I8CXY0